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Clostridium (Clostridioides) difficile infection (CDI) is associated with dysbiosis. C. difficile has a characteristic propensity to persist and recur 1 to 4 weeks after treatment, but the mechanism is unknown. We hypothesized that C.
Charles Darkoh +3 more
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Indole production capacity in three different Escherichia coli strains [PDF]
Background: In Escherichia coli, the enzyme tryptophanase (TnaA) is responsible for the production of indole from tryptophan. However, the factors governing the production and excretion levels of indole by Escherichia coliremain uncertain, complicating ...
Galila Salama +3 more
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Indol production by bacteria [PDF]
ABSTRACT Production of indol by bacteria appears to be limited to those which produce acid from glucose fermentatively and reduce nitrate. From more limited experience, Gram - positive and pigmented bacteria did not produce indol.
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During the transition from exponential to stationary phase E. coli produces a substantial quantity of the small, aromatic signalling molecule indole. In LB medium the supernatant indole concentration reaches a maximum of 0.5-1 mM.
Hannah Gaimster, David Summers
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Characterization of indole-3-pyruvic acid pathway-mediated biosynthesis of auxin in Neurospora crassa. [PDF]
Plants, bacteria and some fungi are known to produce indole-3-acetic acid (IAA) by employing various pathways. Among these pathways, the indole-3-pyruvic acid (IPA) pathway is the best studied in green plants and plant-associated beneficial microbes ...
Puspendu Sardar, Frank Kempken
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Production of indole pigments byCandida glabrata [PDF]
When provided as the sole nitrogen source tryptophan induces the production of several indole alkaloids, e.g., pityriacitrin, malasseziaindole, pityriaanhydride and pityriarubin with proven biological activity in the lipophilic yeast Malassezia furfur. So far these pigments seem to have been unique and only produced by highly specialized basidiomycetal
Mayser, Peter +5 more
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Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity
Gastrointestinal microbes respond to biochemical metabolites that coordinate their behaviors. Here, we demonstrate that bacterial indole functions as a multifactorial mitigator of Klebsiella grimontii and Klebsiella oxytoca pathogenicity.
Nagender Ledala +20 more
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Quorum sensing (QS) is a form of bacterial communication involved in the production of virulence factors in many species. As a result, inhibition of quorum sensing may be of use in mitigating pathogenesis. The signaling molecule indole is currently being
Chesley A. Kemp +3 more
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Targeting the gut microbial metabolic pathway with small molecules decreases uremic toxin production
Uremic toxins are a class of toxins that accumulate in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS), a typical uremic toxin, is not efficiently removed by hemodialysis.
Yingyi Wang +10 more
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Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid
Hypochlorous acid (HOCl) released by activated leukocytes has been implicated in the tissue damage that characterizes chronic inflammatory diseases. In this investigation, 14 indole derivatives, including metabolites such as melatonin, tryptophan and ...
V.F. Ximenes +4 more
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