Results 111 to 120 of about 44,829 (223)

Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer

British Journal of Cancer, 2011
Background:Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolising enzyme that induces immune tolerance by modulating T-cell responses. Carcinomas may create an immunosuppressive state via IDO1 expression.
L. Ferdinande, C. Decaestecker, L. Verset, A. Mathieu, X. M. Lopez, A. Negulescu, T. Maerken, I. Salmon, C. Cuvelier, P. Demetter   +9 more
semanticscholar   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Structure–activity relationship studies of 5-(Pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 inhibitors

Results in Chemistry
Indoleamine 2,3-dioxygenase 1 (IDO1) is the key enzyme that catalyzes the conversion of l-tryptophan (Trp) to N-formyl-kynurenine in the tryptophan-kynurenine (Trp-Kyn) pathway.
Jiawei Zhang, Jingyi Liu, Kaimin Kong, Xingzhou Li, Qian Zhang   +4 more
doaj   +1 more source

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation [PDF]

, 2016
Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines.
Amberger, Barnes, Bradfield, Bruder, Carding, Carlin, Carlin, Costa, Daubener, Daubener, Daubener, Dittrich, Else, Ernst, Ghaemmaghami, Ghaemmaghami, Ghaemmaghami, Gordon, Gosset, Grohmann, Hammad, Hammad, Hayaishi, Hayday, Holt, Hooks, Hunstad, Khademhosseini, Kishimoto, Lambrecht, Langridge, Liu, Mellor, Mellor, Mellor, Mellor, Mellor, Mellor, Mellor, Michelson, Nagase, Namboodiri, Ochs, Opelz, Pallet, Peng, Platten, Platten, Pogue, Puccetti, Puccetti, Puccetti, Puccetti, Raz, Schneider-Schaulies, Schultze, Schwarze, Taylor, Terness, Thomas, Van den Eynde, Van den Eynde, van Oosterhout, Witkiewicz, Wurtzen, Zurawski   +65 more
core   +1 more source

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia

OncoTarget, 2013
Microenvironmental factors contribute to the immune dysfunction characterizing acute myeloid leukemia (AML). Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits
V. Folgiero, B. Goffredo, P. Filippini, R. Masetti, G. Bonanno, R. Caruso, V. Bertaina, A. Mastronuzzi, S. Gaspari, M. Zecca, G. Torelli, A. Testi, A. Pession, F. Locatelli, S. Rutella   +14 more
semanticscholar   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma [PDF]

, 2020
Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy.
Bhushan, Alok, Kaushal, Gagan, Lam, Bao, Link, Emma, Londin, Eric R, Orloff, Marlana, Rochani, Ankit, Sato, Takami, Terai, Mizue   +8 more
core   +1 more source

Disease-induced neuroinflammation and depression [PDF]

, 2016
Progression of major depression, a multifactorial disorder with a neuroinflammatory signature, seems to be associated with the disruption of body allostasis.
ALBONI, Silvia, BENATTI, Cristina, BLOM, Johanna Maria Catharina, BRUNELLO, Nicoletta, RIGILLO, GIOVANNA, TASCEDDA, Fabio, Torta, Riccardo, Zizzi, Francesca   +7 more
core   +1 more source

Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process

Ageing Research Reviews, 2022
A. Salminen
semanticscholar   +1 more source