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Dual Role of Indoles Derived From Intestinal Microbiota on Human Health
Frontiers in Immunology, 2022 Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities.
Xuewei Ye +9 more
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Synthesis of Indole Derivatives via Aryl Triazole Ring-Opening and Subsequent Cyclization [PDF]
MoleculesA metal-free two-step synthetic approach for obtaining indole derivatives from aryl triazole fragment-containing compounds has been developed. In the first step, the Dimroth equilibrium, followed by nitrogen extrusion, Wolff rearrangement, and amine ...
Aleksejs Burcevs +4 more
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Aniline is an inducer, and not a precursor, for indole derivatives in Rubrivivax benzoatilyticus JA2. [PDF]
PLoS ONE, 2014 Rubrivivax benzoatilyticus JA2 and other anoxygenic photosynthetic bacteria produce indole derivatives when exposed to aniline, a xenobiotic compound. Though this phenomenon has been reported previously, the role of aniline in the production of indoles ...
Mohammed Mujahid +2 more
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Microbiology Spectrum, 2022 The Gram-positive anaerobic bacterium Cutibacterium acnes is a major inhabitant of human skin and has been implicated in acne vulgaris formation and in the formation of multispecies biofilms with other skin-inhabiting organisms like Staphylococcus aureus
Yong-Guy Kim +3 more
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Communications Chemistry, 2021 Dearomatisation of indoles allows efficient access to indolines, but often is incompatible with electron-withdrawing substituents. Here a photoredox Giese-type dearomatisation of indoles yields 2,3-disubstituted indolines bearing electron-withdrawing ...
Yueteng Zhang +7 more
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Ruthenium-Catalyzed Oxidative Synthesis of N-(2-triazine)indoles by C-H Activation
Molecules, 2023 1,3,5 triazines, especially indole functionalized triazine derivatives, exhibit excellent activities, such as anti-tumor, antibacterial, and anti-inflammatory activities.
Ming Zeng +7 more
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BMC Plant Biology, 2023 Background Strobilanthes cusia (Nees) Kuntze is a traditional medical plant distributed widely in south China. The indole compounds that originated from the plant are responsible for its pharmacological activities.
Chang Liu +4 more
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Nano-Fe3O4 catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities [PDF]
شیمی کاربردی روز, 2014 Indoles are one of the most prevalent heterocyclic compounds, which are present as the basic cores in many natural products potent pharmaceutical compounds. Despite numerous diverse approaches toward the synthesis of indoles developed so far, it is still
Seyyedeh Cobra Azimi
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Specific versus Nonspecific Solvent Interactions of a Biomolecule in Water [PDF]
J. Phys. Chem. Lett. 14, 10499-10508 (2023), 2022 Solvent interactions, particularly hydration, are vital in chemical and biochemical systems. Model systems unveil microscopic details of such interactions. We uncover a specific hydrogen-bonding motif of the biomolecular building block indole (C$_8$H$_7$N), tryptophan's chromophore, in water: a strong localized $\text{N-H}\cdots\text{OH}_2$ hydrogen ...
arxiv +1 more source
Recent Progress Concerning the N-Arylation of Indoles
Molecules, 2021 This review summarizes the current state-of-the-art procedures in terms of the preparation of N-arylindoles. After a short introduction, the transition-metal-free procedures available for the N-arylation of indoles are briefly discussed. Then, the nickel-
Petr Oeser +3 more
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