Results 21 to 30 of about 27,606 (220)

Synthesis and X-ray Crystal Structure Analysis of Substituted 1,2,4-Triazolo [4’,3’:2,3]pyridazino[4,5-b]indole and Its Precursor

Crystals, 2023
The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was ...
Ahmed T. A. Boraei, Elsayed H. Eltamany, Matti Haukka, Saied M. Soliman, Assem Barakat, Manar Sopaih   +5 more
doaj   +1 more source

Chemoselective N-acylation of indoles using thioesters as acyl source

Beilstein Journal of Organic Chemistry, 2022
The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A
Tianri Du, Xiangmu Wei, Honghong Xu, Xin Zhang, Ruiru Fang, Zheng Yuan, Zhi Liang, Yahui Li   +7 more
doaj   +1 more source

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

Frontiers in Immunology, 2023
IntroductionStaphylococcus epidermidis is a commensal bacterium ubiquitously present on human skin. This species is considered as a key member of the healthy skin microbiota, involved in the defense against pathogens, modulating the immune system, and ...
Leslie Landemaine, Leslie Landemaine, Gregory Da Costa, Gregory Da Costa, Elsa Fissier, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Marie-Laure Michel, Romain Briandet, Harry Sokol, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Philippe Langella, Cecile Clavaud, Mathias L. Richard, Mathias L. Richard   +23 more
doaj   +1 more source

A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction

Molecules
3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring ...
Felix Potlitz, Gottfried J. Palm, Anja Bodtke, Michael Lammers, Dennis Schade, Andreas Link   +5 more
doaj   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source

A General and Scalable Synthesis of Polysubstituted Indoles

Molecules, 2020
A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported.
David Tejedor, Raquel Diana-Rivero, Fernando García-Tellado   +2 more
doaj   +1 more source

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

Molecules, 2020
The 1,3-benzothiazole (BTZ) ring may offer a valid option for scaffold-hopping from indole derivatives. Several BTZs have clinically relevant roles, mainly as CNS medicines and diagnostic agents, with riluzole being one of the most famous examples ...
Serge Mignani, Jean-Pierre Majoral, Jean-François Desaphy, Giovanni Lentini   +3 more
doaj   +1 more source

Base-Promoted S_NAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

Molecules, 2019
KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has ...
Muhammad Asif Iqbal, Hina Mehmood, Jiaying Lv, Ruimao Hua   +3 more
doaj   +1 more source

Synthesis, Characterization, Fluorescence Properties, and DFT Modeling of Difluoroboron Biindolediketonates

Molecules, 2023
We report a simple and efficient strategy to enhance the fluorescence of biocompatible biindole diketonates (bdks) in the visible spectrum through difluoroboronation (BF2bdks complexes).
Angelo Maspero, Federico Vavassori, Luca Nardo, Guglielmo Vesco, Jenny G. Vitillo, Andrea Penoni   +5 more
doaj   +1 more source

Boron Trifluoride Etherate Promoted Regioselective 3-Acylation of Indoles with Anhydrides

Molecules, 2022
An efficient, high-yielding and scalable procedure for the regioselective 3-acylation of indoles with anhydrides promoted by boron trifluoride etherate under mild conditions was reported. This novel protocol provided a simple way to prepare 3-(benzofuran-
Yunyun Zheng, Jiuling Li, Kai Wei
doaj   +1 more source