Results 31 to 40 of about 172,313 (331)
Frontiers in Chemistry, 2019 A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi +7 more
doaj +1 more source
Green Synthesis and Catalysis, 2021 A convenient method for the rapid construction of indolo[2,3-b]indoles has been developed. This cascade reaction involving condensation, dehydroaromatization, and oxidative annulation was achieved in a one-pot TMSI/DMSO system, providing a diversity of ...
Pingyu Jiang +5 more
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Myoglobin-Catalyzed C-H Functionalization of Unprotected Indoles.
Angewandte Chemie, 2018 Functionalized indoles are recurrent motifs in bioactive natural products and pharmaceuticals. While transition metal-catalyzed carbene transfer has provided an attractive route to afford C3-functionalized indoles, these protocols are viable only in the ...
David A Vargas +3 more
semanticscholar +1 more source
A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction
Molecules3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring ...
Felix Potlitz +5 more
doaj +1 more source
MicrobiomeBackground The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology.
Gang Wang +9 more
semanticscholar +1 more source
Blood, 2018 The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or
A. Swimm +11 more
semanticscholar +1 more source
Synthesis of Indoles and Pyrroles Utilizing Iridium Carbenes Generated from Sulfoxonium Ylides.
Angewandte Chemie, 2017 Metal carbenes can undergo a myriad of synthetic transformations. Sulfur ylides are potential safe precursors of metal carbenes. Herein, we report cascade reactions that involve carbenoids derived from sulfoxonium ylides for the efficient and ...
Janakiram Vaitla +2 more
semanticscholar +1 more source
Antibiofilm and Antivirulence Properties of Indoles Against Serratia marcescens
Frontiers in Microbiology, 2020 Indole and its derivatives have been shown to interfere with the quorum sensing (QS) systems of a wide range of bacterial pathogens. While indole has been previously shown to inhibit QS in Serratia marcescens, the effects of various indole derivatives on
Sivasamy Sethupathy +4 more
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Base-Promoted SNAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
Molecules, 2019 KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has ...
Muhammad Asif Iqbal +3 more
doaj +1 more source