Results 31 to 40 of about 104,731 (310)

Chemoselective N-acylation of indoles using thioesters as acyl source

Beilstein Journal of Organic Chemistry, 2022
The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A
Tianri Du, Xiangmu Wei, Honghong Xu, Xin Zhang, Ruiru Fang, Zheng Yuan, Zhi Liang, Yahui Li   +7 more
doaj   +1 more source

Synthesis and X-ray Crystal Structure Analysis of Substituted 1,2,4-Triazolo [4’,3’:2,3]pyridazino[4,5-b]indole and Its Precursor

Crystals, 2023
The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was ...
Ahmed T. A. Boraei, Elsayed H. Eltamany, Matti Haukka, Saied M. Soliman, Assem Barakat, Manar Sopaih   +5 more
doaj   +1 more source

HBF4 Catalysed Nucleophilic Substitutions of Propargylic Alcohols [PDF]

, 2015
The activity of HBF4 (aqueous solution) as a catalyst in propargylation reactions is presented. Diverse types of nucleophiles were employed in order to form new C–O, C–N and C–C bonds in technical acetone and in air.
Barreiro, EB, Diez-Gonzalez, S, Lau, SHL, Sanz Vidal, ASV, Sheppard, TS, Tan, ET   +5 more
core   +2 more sources

Formation of Bicyclic Pyrroles from the Catalytic Coupling Reaction of 2,5-disubstituted Pyrroles with Terminal Alkynes, Involving the Activation of Multiple C-H bonds [PDF]

, 2008
Substituted bicyclic pyrroles are produced directly from the coupling reaction of 2,5-disubstituted pyrroles with terminal alkynes, involving the activation of multiple C–H bonds and regioselective ...
Yi, Chase S., Zhang, Jie
core   +2 more sources

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. [PDF]

, 2009
Pharmacological suppression of leukotriene biosynthesis by inhibitors of 5-lipoxygenase (5-LO) is a strategy to intervene with inflammatory and allergic disorders.
BÜHRING U, KARG EM, LUDERER S, NORTHOFF H, PERGOLA C, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, TROSCHÜTZ R, WERZ O.   +8 more
core   +1 more source

A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction

Molecules
3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring ...
Felix Potlitz, Gottfried J. Palm, Anja Bodtke, Michael Lammers, Dennis Schade, Andreas Link   +5 more
doaj   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source

A General and Scalable Synthesis of Polysubstituted Indoles

Molecules, 2020
A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported.
David Tejedor, Raquel Diana-Rivero, Fernando García-Tellado   +2 more
doaj   +1 more source

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

Frontiers in Immunology, 2023
IntroductionStaphylococcus epidermidis is a commensal bacterium ubiquitously present on human skin. This species is considered as a key member of the healthy skin microbiota, involved in the defense against pathogens, modulating the immune system, and ...
Leslie Landemaine, Leslie Landemaine, Gregory Da Costa, Gregory Da Costa, Elsa Fissier, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Marie-Laure Michel, Romain Briandet, Harry Sokol, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Philippe Langella, Cecile Clavaud, Mathias L. Richard, Mathias L. Richard   +23 more
doaj   +1 more source

Synthesis and alkyne-coupling chemistry of cyclomanganated 1- and 3-acetylindoles, 3-formylindole and analogues [PDF]

, 2006
The syntheses are reported of new cyclomanganated indole derivatives (1-acetyl-κO-indolyl-κC2)dicarbonylbis(trimethylphosphite)manganese (2), (1-methyl-3-acetyl-κO-indolyl-κC2)tetracarbonylmanganese (4), (3-formyl-κO-indolyl-κC2)tetracarbonylmanganese ...
Depree, Gary J., Jameson, Geoffrey B., Main, Lyndsay, Nicholson, Brian K., Robinson, Nicholas P.   +4 more
core   +2 more sources