Results 221 to 230 of about 223,235 (338)

Development of a novel in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes. [PDF]

Genes Environ
Kobayashi R, Sasaki K, Matsuyama R, Saito K, Kumagai A, Kitayama S, Kawai Y, Kaneko S.   +7 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Human induced pluripotent stem cell-derived cardiomyocytes improve recovery from myocardial infarction in non-human primates. [PDF]

Stem Cell Res Ther
Guan X, Zhang P, Wang Q, Zhang Y, Zhang Y, Zhang H, Zhang H, Jiang W, Wu Y, Wang X, Wang D, Wang J, Gao L.   +12 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Generation of an induced pluripotent stem cell line, JHUi008-A, from a healthy female donor. [PDF]

Stem Cell Res
Chua CJ, DiSilvestre D, Joshi-Mukherjee R, Tung L, Tomaselli GF, Boheler KR.   +5 more
europepmc   +1 more source

Differentiation of Human Induced Pluripotent Stem Cells Toward Implantable Chondroprogenitor Cells

Josefine Ekholm, Kristina Vukušić, Camilla Brantsing, Georgina Shaw, Fazal‐Ur‐Rehman Bhatti, Stina Simonsson, Anna Falk, Mary Murphy, Victoria Rotter Sopasakis, Anders Lindahl   +9 more
openalex   +1 more source

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Human-Induced Pluripotent Stem Cell Models for Amyloid Cardiomyopathy: From Mechanistic Insights to Therapeutic Discovery. [PDF]

J Cardiovasc Dev Dis
Liu Y, Riaz M.
europepmc   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, EarlyView.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Generation of human induced pluripotent stem cell lines from patients with PHACE syndrome. [PDF]

Stem Cell Res
Ramchandani R, Cheawsamoot C, Torres GA, Arthur Ataam J, Siegel D, Karakikes I.   +5 more
europepmc   +1 more source