Results 221 to 230 of about 310,335 (273)

Trametinib alters contractility of paediatric Noonan syndrome‐associated hypertrophic myocardial tissue slices

ESC Heart Failure, EarlyView.
Abstract Aims No curative treatment is available for RASopathy‐associated childhood‐onset hypertrophic cardiomyopathy (RAS‐CM). Preclinical data and individual reports suggest a beneficial effect of small molecules targeting the RAS–mitogen‐activated protein (MAP) kinase (MAPK) pathway in severely affected RAS‐CM patients.
Jules Hamers, Payel Sen, Sarala Raj Murthi, Laura Papanakli, Maria von Stumm, Francesca Baessato, Julie Cleuziou, Christian Meierhofer, Peter Ewert, Andreas Dendorfer, Daphne Merkus, Cordula M. Wolf   +11 more
wiley   +1 more source

Extracellular matrix proteins refine microenvironments for pancreatic organogenesis from induced pluripotent stem cell differentiation. [PDF]

Theranostics
Hu M, Liu T, Huang H, Ogi D, Tan Y, Ye K, Jin S.   +6 more
europepmc   +1 more source

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets

ESC Heart Failure, EarlyView.
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley   +1 more source

Breakthrough in human induced pluripotent stem cell research of a functional cure for type 1 diabetes. [PDF]

Innovation (Camb)
Xu M, Ning G.
europepmc   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Chromosome number alterations cause apoptosis and cellular hypertrophy in induced pluripotent stem cell models of embryonic epiblast cells. [PDF]

Biol Open
Martis ASA, Soundararajan L, Shetty P, Moin S, Vanje T, Jai Sankar Y, Parveen S.   +6 more
europepmc   +1 more source

Induced Pluripotent Stem Cell-Derived Parathyroid Organoids Resemble Parathyroid Morphology and Function. [PDF]

Adv Sci (Weinh)
Şenkal-Turhan S, Bulut-Okumuş E, Aydın M, Başak Türkmen N, Taşlıdere A, Şahin F, Yılmaz Ş, Akkuş Süt P, Doğan A.   +8 more
europepmc   +1 more source

An African perspective on genetically diverse human induced pluripotent stem cell lines. [PDF]

Nat Commun
Hurrell T, Naidoo J, Ntlhafu T, Scholefield J.   +3 more
europepmc   +1 more source

Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

Food Frontiers, EarlyView.
Organ‐on‐chips offer a promising tool for evaluating food and feed safety. Organ‐on‐chips also present a scientifically robust and ethical alternative to animal studies. ABSTRACT The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, recognizing that the health of each is interdependent and influenced by ...
Manuela Cassotta, Maria Elexpuru‐Zabaleta, Sandra Sumalla Cano, Yasmany Armas Diaz, Francesca Giampieri, Zou Xiaobo, Di Zhang, Giuseppe Grosso, Maurizio Battino   +8 more
wiley   +1 more source

A human induced pluripotent stem cell toolbox for studying sex chromosome effects

Meleckyte R, Varsally W, Zohren J, Eriksson J, Incitti T, Starnes L, Pointon A, Hicks R, Powell BE, Turner JM.   +9 more
europepmc   +1 more source