Results 231 to 240 of about 310,335 (273)

Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell-Derived Hepatocytes that is Influenced by Disease State of the Donor. [PDF]

Gastro Hep Adv
Minocha E, Jiang L, Gupta AK, Green RM, Zohar Y, Wertheim JA.   +5 more
europepmc   +1 more source

Advances in induced pluripotent stem cell research for neurological diseases

, 2010
Daisuke Ito, Takuya Yagi, Yoshihiro Nihei, Takahito Yoshizaki, Norihiro Suzuki   +4 more
openalex   +2 more sources

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia

Glia, EarlyView.
ABSTRACT The SORL1 gene encodes the sortilin‐related receptor protein SORLA, a sorting receptor that regulates endo‐lysosomal trafficking of various substrates. Loss of function variants in SORL1 are causative for Alzheimer's disease (AD) and decreased expression of SORLA has been repeatedly observed in human AD brains. SORL1 is highly expressed in the
Swati Mishra, Nader Morshed, Sonia Beant Sidhu, Chizuru Kinoshita, Beth Stevens, Suman Jayadev, Jessica E. Young   +6 more
wiley   +1 more source

Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes. [PDF]

PLoS One
Bommer T, Knierim M, Unsöld J, Riedl D, Stengel L, Paulus M, Körtl T, Liaw N, Maier LS, Streckfuss-Bömeke K, Sossalla S, Pabel S.   +11 more
europepmc   +1 more source

Fibroblasts and hiPS‐Derived Astrocytes From CoPAN Patients Showed Different Levels of Iron Overload Correlated With Senescent Phenotype

Glia, EarlyView.
CoPAN affects CoA biosynthesis and leads to iron dyshomeostasis. CoPAN d‐astrocytes show ferroptosis, iron accumulation, senescence, lipid peroxidation, mitochondrial damage and tubulin acetylation loss. Astrocytes recapitulate CoPAN disease. ABSTRACT COASY protein‐associated neurodegeneration (CoPAN) is a rare autosomal recessive disorder within the ...
Anna Cozzi, Paolo Santambrogio, Andrea Stefano Moro, Alessio Pelagatti, Alicia Rubio, Chiara Balestrucci, Ivano Di Meo, Valeria Tiranti, Sonia Levi   +8 more
wiley   +1 more source

Efficacy of Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cell Replacement Therapy in a Vascular Dementia Animal Model. [PDF]

Tissue Eng Regen Med
Kim JH, Kang HY, Lee J, Kim JH, Geum D, Park DH.   +5 more
europepmc   +1 more source

Generation of induced pluripotent stem cells using site-specific integration with phage integrase

, 2010
Lin Ye, Judy C. Chang, Chin Jia Lin, Zhongxia Qi, Jingwei Yu, Yuet Wai Kan   +5 more
openalex   +1 more source

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Glia, EarlyView.
FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte‐mediated neurotoxicity. FABP7 silencing attenuates NF‐κB‐dependent transcriptional response during endotoxemia. ABSTRACT Fatty acid binding proteins (FABPs) are a family of small proteins involved in fatty acid (FA) subcellular trafficking.
Mariana Bresque, Daniel Esteve, Garret Balmer, Haylee L. Hamilton, Joshua S. Stephany, Mariana Pehar, Marcelo R. Vargas   +6 more
wiley   +1 more source

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Preclinical Cardiotoxicity Screening in Cardio-Oncology. [PDF]

JACC CardioOncol
Shead KD, Huethorst E, Burton F, Lang NN, Myles RC, Smith GL.   +5 more
europepmc   +1 more source

Epigenetic memory in induced pluripotent stem cells

, 2010
K. Kim, Akiko Doi, Bo Wen, Kelvin S. Ng, Robert Chunhua Zhao, Patrick Cahan, Jonghwan Kim, Martin J. Aryee, Hong Ji, Lauren I. R. Ehrlich, Akiko Yabuuchi, Ayumu Takeuchi, K. C. Cunniff, Hongguang Huo, Shannon McKinney‐Freeman, Olaia Naveiras, Taeyeong Yoon, Rafael A. Irizarry, Namyoung Jung, Jun Seita, Jacob H. Hanna, Peter Murakami, Rudolf Jaenisch, Ralph Weissleder, Stuart H. Orkin, Irving L. Weissman, Andrew P. Feinberg, George Q. Daley   +27 more
openalex   +2 more sources