Results 231 to 240 of about 390,247 (379)

A simple and efficient cryopreservation method for feeder-free dissociated human induced pluripotent stem cells and human embryonic stem cells [PDF]

, 2009
Sepideh Mollamohammadi, A Taei, Mohammad Pakzad, Mehdi Totonchi, Ali Seifinejad, Naser Masoudi, Hossein Baharvand   +6 more
openalex   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks

Advanced Science, EarlyView.
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie, Caihong Zheng, Likun Ren, Yue Teng, Yaoyu Sun, Lifei Wang, Junya Li, Jun Cai   +7 more
wiley   +1 more source

A comprehensive analysis of induced pluripotent stem cell (iPSC) production and applications. [PDF]

Front Cell Dev Biol
Matiukhova M, Ryapolova A, Andriianov V, Reshetnikov V, Zhuravleva S, Ivanov R, Karabelsky A, Minskaia E.   +7 more
europepmc   +1 more source

Tumorigenicity of Human Induced Pluripotent Stem Cells Depends on the Balance of Gene Expression Between P21 and P53 [PDF]

, 2009
Hisashi Moriguchi, Raymond T. Chung, Chifumi Sato   +2 more
openalex   +1 more source

m6A Modulates RAN Translation From CAG Repeat Expansion RNA

Aggregate, EarlyView.
We described a novel role of N6‐methyladenosine in promoting non‐canonical repeat‐associated non‐AUG translation from CAG repeat expansion RNA. ABSTRACT Nucleotide repeat expansions contribute to the development of a number of neurodegenerative diseases.
Yuxiang Sun, Zhouxian Li, Hui Dai, Yinsheng Wang   +3 more
wiley   +1 more source

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose‐derived stem cells via the hsa‐miR‐647/SOX9 pathway

Animal Models and Experimental Medicine, EarlyView.
The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou, Huajun Wang, Hao Guo, Dongbin Luo, Xiaofei Zheng, Simin Luo   +5 more
wiley   +1 more source

Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis. [PDF]

Front Hum Neurosci
Sun Y, Liu Z, Zhang Z, Kang Y, Wang X, Zhang Y, Liu Y, Zhao P.   +7 more
europepmc   +1 more source

Generation of Induced Pluripotent Stem Cells by Reprogramming Mouse Embryonic Fibroblasts with a Four Transcription Factor, Doxycycline Inducible Lentiviral Transduction System [PDF]

, 2009
Brad Hamilton, Qiang Feng, Mike Ye, G. Grant Welstead   +3 more
openalex   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source