Results 111 to 120 of about 496,668 (364)

A Quantum Model on Chemically-Physically Induced Pluripotency in Stem Cells [PDF]

arXiv, 2013
A quantum model on the chemically and physically induced pluripotency in stem cells is proposed. Based on the conformational Hamiltonian and the idea of slow variables (molecular torsions) slaving fast ones the conversion from the differentiate state to pluripotent state is defined as the quantum transition between conformational states.
arxiv  

Transcriptional profiling reveals fundamental differences in iPS-derived progenitors of endothelial cells (PECs) versus adult circulating EPCs [PDF]

arXiv, 2020
There are a number of different stem cell sources that have the potential to be used as therapeutics in vascular degenerative diseases. On the one hand, there are so called endothelial progenitor cells (EPCs), which are typically derived from adult blood. They carry the marker CD34, but the true nature and definition of EPCs is still controversial.
arxiv  

A Visible Light‐Responsive Hydrogel to Study the Effect of Dynamic Tissue Stiffness on Cellular Mechanosensing

Advanced Functional Materials, EarlyView.
A visible light‐responsive polyacrylamide‐azobenzene hydrogel enables safe, reversible stiffness control for studying cell mechanobiology without harmful UV exposure. This approach reveals stem cells respond rapidly to mechanical changes, showing altered shape and protein distribution within one hour.
Aafreen Ansari, Sanchyan Bhowmik, Kaiwen Zhang, Chayla L. Reeves, Danielle Vahala, Yu Suk Choi, Amy Gelmi, Alexander N. Combes, Rocky S. Tuan, Vinh X. Truong, John S. Forsythe, Jessica E. Frith   +11 more
wiley   +1 more source

Theoretical modelling discriminates the stochastic and deterministic hypothesis of cell reprogramming [PDF]

arXiv, 2014
How to induce differentiated cells into pluripotent cells has elicited researchers' interests for a long time since pluripotent stem cells are able to offer remarkable potential in numerous subfields of biological research. However, the nature of cell reprogramming, especially the mechanisms still remain elusive for the sake of most protocols of ...
arxiv  

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids [PDF]

, 2019
Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue, but lacks functional information. We present dynamic full-field optical coherence tomography to image living human induced pluripotent stem cell-derived retinal organoids non-invasively.
arxiv   +1 more source

Pericyte‐Assisted Vascular Lumen Organization in a Novel Dynamic Human Blood‐Brain Barrier‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Organ‐on‐Chip (OoC) technology enables the precise modeling of the blood‐brain barrier (BBB). This study presents a microfluidic device that mimics brain microvessels, integrating co‐culture with pericytes and astrocytes under pulsatile flow. Results show that perivascular cells modulate endothelial morphology, promoting lumen formation and barrier ...
Vita Guarino, Elisabetta Perrone, Elisa De Luca, Alberto Rainer, Maura Cesaria, Alessandra Zizzari, Monica Bianco, Giuseppe Gigli, Lorenzo Moroni, Valentina Arima   +9 more
wiley   +1 more source

The recent advances in the mathematical modelling of human pluripotent stem cells [PDF]

arXiv, 2019
Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessary to understand and quantify key behaviours and develop non-invasive prognostic modelling tools to assist in the optimisation of laboratory experiments.
arxiv  

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

Nature Communications, 2018
Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental biology and regenerative medicine, notably because they circumvent the use of cells of embryonic origin and offer the potential to generate patient-specific pluripotent
Stéphanie Kilens, D. Meistermann, Diego Moreno, Caroline Chariau, A. Gaignerie, A. Reignier, Yohann Lelièvre, Miguel Casanova, C. Vallot, S. Nedellec, Léa Flippe, J. Firmin, Juan Song, Eric Charpentier, J. Lammers, Audrey Donnart, Nadège Marec, W. Deb, Audrey Bihouée, C. Le Caignec, C. Pecqueur, R. Redon, P. Barrière, Jérémie Bourdon, V. Pasque, M. Soumillon, T. Mikkelsen, C. Rougeulle, T. Fréour, L. David, Laurent Andres Kalla Philippe Pierre Ana Darragh Caroline Abel Alcover Astrom Bousso Bruhns Cumano Duffy Dem, L. Abel, A. Alcover, Kalla Astrom, P. Bousso, P. Bruhns, A. Cumano, D. Duffy, C. Demangel, L. Deriano, J. D. Di Santo, F. Dromer, G. Eberl, J. Enninga, J. Fellay, Antonio Freitas, Odile Gelpi, Ivo Gomperts-Boneca, S. Hercberg, O. Lantz, C. Leclerc, H. Mouquet, E. Patin, S. Pellegrini, S. Pol, L. Rogge, A. Sakuntabhai, O. Schwartz, Benno Schwikowski, S. Shorte, V. Soumelis, F. Tangy, E. Tartour, A. Toubert, M. Ungeheuer, L. Quintana-Murci, M. Albert   +66 more
semanticscholar   +1 more source

Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells

Advanced Healthcare Materials, EarlyView.
This study presents a custom‐made soft pneumatic device (SPD) that mimics complex mechanical forces and fluid flow to enhance in vitro cell differentiation. It shows that low mechanotransduction promotes MSC differentiation into osteoprogenitor cells, while high mechanotransduction causes structural disruptions and cell detachment, providing new ...
Gwang‐Bum Im, Jae Gyeong Lee, Hosub Lim, Jae‐Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak‐Rin Kim, Jeong Jae Wie, Suk Ho Bhang   +9 more
wiley   +1 more source