Results 201 to 210 of about 8,076,620 (303)

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Human induced pluripotent stem cells and organoid models in space for investigating severe pediatric metabolic and congenital disorders. [PDF]

Precis Clin Med
Benedetti S, Štupica H, Zuccotti GV, Weissig V, Marotta D, Pappone C, Tull A, Rubins KH, Beheshti A, Mason CE, Ferraro S.   +10 more
europepmc   +1 more source

Optimizing Electrode Design for Functional Activation of Human Pluripotent Stem Cell‐Derived Cardiomyocytes

Advanced NanoBiomed Research, EarlyView.
Electrical stimulation of human pluripotent stem cell‐derived cardiomyocytes is systematically investigated as a function of electrode material and configuration. Stimulation efficiency is found to be governed predominantly by electrode geometry, with increased electrode area and proximity to cells enabling more effective pacing.
Gustavo Ramirez‐Calderon, Abdulelah Saleh, Tania Cecilia Hidalgo Castillo, Anil Koklu, Adel Hama, Gabriel Herrera‐Lopez, Veronica Astro, Yazmin Hernández Mustafá, Plácido D. Jorge Collet, Lamia Bin Thuwaini, Pierre J. Magistretti, Antonio Adamo, Sahika Inal   +12 more
wiley   +1 more source

Epigenomic regulation of neural crest differentiation in human-induced pluripotent stem cells. [PDF]

iScience
Mukae K, Shindo M, Shi T, Onuki R, Yamashita S, Hattori N, Ushijima T, Ohira M, Kamijo T.   +8 more
europepmc   +1 more source

The Fragile Site Landscape of Induced Pluripotent Stem Cells: Hierarchy, Variability, Tissue Specificity, and Links to Culture-Acquired Rearrangements. [PDF]

Cells
Pozhitnova VO, Zheglo D, Kislova AV, Kiselev DS, Voronina ES.   +4 more
europepmc   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Generation of alveolar organoids from human induced pluripotent stem cells using a stirred-tank bioreactor. [PDF]

Front Bioeng Biotechnol
Budeus B, Cremer L, Sevindik ZF, Klein D.   +3 more
europepmc   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Induced Pluripotent Stem Cells in Corneal Regeneration: Biological Progress, Translational Barriers and Clinical Outlook. [PDF]

Biomedicines
Al-Amarat TS, Mehta JS.
europepmc   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source