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Routes to induced pluripotent stem cells
Current Opinion in Genetics & Development, 2014The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of hundreds of genes, making unique ...
Tyson Ruetz, Keisuke Kaji
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Induced Pluripotent Stem Cells
2022A limiting factor for the identification of disease mechanisms and development of new therapies has been the access to a model system/s that can faithfully recapitulate key features of the disease and more precise clinical translations of new treatments.
Ambrin Fatima, Uzma Abdullah, Zafar Ali
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Mouse-Induced Pluripotent Stem Cells
2012Pluripotent stem cells belong to a unique population of cells, which can self-renew indefinitely and have the potential to give rise to all cell types in an organism. Generally, pluripotent stem cells include embryonic stem cells (ESCs), embryonic germ cells (EGCs), and embryonal carcinoma cells (ECCs) (Boiani and Scholer 2005).
Hui, Zhang, Ying, Jin
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Generation of Induced Pluripotent Stem Cells
2014Induced pluripotent stem cells (iPSCs) are generated from somatic cells that have been reprogrammed by the ectopic expression of defined embryonic transcription factors. This technology has provided investigators with a powerful tool for modeling disease and developing treatments for human disorders.
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Stem Cells, Induced Pluripotent
2021Induced pluripotent stem cells (iPSCs) refer to a type of stem cell directly generated using reprogramming techniques from multipotent adult stem cells. Therefore iPSCs gained a lower level of differentiation and could present themselves as pluripotent.
Henk ten Have +1 more
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Generation of Induced Pluripotent Stem Cells in Rabbits
2014We describe a procedure for generating induced pluripotent stem cell lines in rabbits, using retroviral vectors expressing Oct4, Sox2, Klf4, and c-Myc of human origin to reprogram rabbit fibroblasts prepared from an ear skin biopsy. We also provide detailed procedures for characterizing the resulting iPSC lines, including the analysis of pluripotency ...
Afanassieff, Marielle +2 more
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Induced Pluripotent Stem Cells — A Cautionary Note
New England Journal of Medicine, 2011There are two sources of the human pluripotent stem cell — the differentiated somatic cell, such as a skin fibroblast, and the embryo. Recent studies suggest that an extra level of caution is warranted in using stem cells derived from somatic cells.
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A safer stem cell: inducing pluripotency
Nature Medicine, 2009Laura, Clarke, Derek, van der Kooy
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Induced pluripotent stem cells: the new patient?
Nature Reviews Molecular Cell Biology, 2012Milena Bellin +2 more
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Induced pluripotent stem cells — opportunities for disease modelling and drug discovery
Nature Reviews Drug Discovery, 2011Berta Strulovici +2 more
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