Results 221 to 230 of about 121,384 (261)

Livestock Induced Pluripotent Stem Cells

Reproduction in Domestic Animals, 2012
ContentsChimeric animals generated from livestock‐induced pluripotent stem cells (iPSCs) have opened the door of opportunity to genetically manipulate species for the production of biomedical models, improving traits of agricultural importance and potentially providing a system to test novel iPSC therapies.
Y, Lu, J L, Mumaw, F D, West, S L, Stice
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Routes to induced pluripotent stem cells

Current Opinion in Genetics & Development, 2014
The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of hundreds of genes, making unique ...
Tyson Ruetz, Keisuke Kaji
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Induced Pluripotent Stem Cells

2022
A limiting factor for the identification of disease mechanisms and development of new therapies has been the access to a model system/s that can faithfully recapitulate key features of the disease and more precise clinical translations of new treatments.
Ambrin Fatima, Uzma Abdullah, Zafar Ali
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Mouse-Induced Pluripotent Stem Cells

2012
Pluripotent stem cells belong to a unique population of cells, which can self-renew indefinitely and have the potential to give rise to all cell types in an organism. Generally, pluripotent stem cells include embryonic stem cells (ESCs), embryonic germ cells (EGCs), and embryonal carcinoma cells (ECCs) (Boiani and Scholer 2005).
Hui, Zhang, Ying, Jin
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Generation of Induced Pluripotent Stem Cells

2014
Induced pluripotent stem cells (iPSCs) are generated from somatic cells that have been reprogrammed by the ectopic expression of defined embryonic transcription factors. This technology has provided investigators with a powerful tool for modeling disease and developing treatments for human disorders.
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Stem Cells, Induced Pluripotent

2021
Induced pluripotent stem cells (iPSCs) refer to a type of stem cell directly generated using reprogramming techniques from multipotent adult stem cells. Therefore iPSCs gained a lower level of differentiation and could present themselves as pluripotent.
Henk ten Have, Maria do Céu Patrão Neves   +1 more
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Generation of Induced Pluripotent Stem Cells in Rabbits

2014
We describe a procedure for generating induced pluripotent stem cell lines in rabbits, using retroviral vectors expressing Oct4, Sox2, Klf4, and c-Myc of human origin to reprogram rabbit fibroblasts prepared from an ear skin biopsy. We also provide detailed procedures for characterizing the resulting iPSC lines, including the analysis of pluripotency ...
Afanassieff, Marielle, Tapponnier, Yann, Savatier, Pierre   +2 more
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Induced Pluripotent Stem Cells — A Cautionary Note

New England Journal of Medicine, 2011
There are two sources of the human pluripotent stem cell — the differentiated somatic cell, such as a skin fibroblast, and the embryo. Recent studies suggest that an extra level of caution is warranted in using stem cells derived from somatic cells.
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A safer stem cell: inducing pluripotency

Nature Medicine, 2009
Laura, Clarke, Derek, van der Kooy
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A METHOD OF GENERATING AN INDUCED PLURIPOTENT STEM CELL, AN INDUCED PLURIPOTENT STEM CELL AND METHODS OF USING THE INDUCED PLURIPOTENT STEM CELL

2022
CHAI CHOU, LIM KAH LEONG, PHAN TOAN THANG   +2 more
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