Results 211 to 220 of about 121,384 (261)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Anti-inflammatory and immunomodulatory effects of human induced pluripotent stem cells-derived mesenchymal stem/stromal cells and their extracellular vesicles. [PDF]

Regen Ther
Komoike Y, Kamiya D, Sasaki-Ban H, Matsuda A, Matsumoto H, Ikeya M.   +5 more
europepmc   +1 more source

Origin of chromosome 12 trisomy surge in human induced pluripotent stem cells. [PDF]

J Cell Biol
Narozna M, Latham MC, Gorbsky GJ.
europepmc   +1 more source

Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines. [PDF]

Front Immunol
Kuebler B, Selvitella S, Aran B, Raya A, Veiga A.   +4 more
europepmc   +1 more source

Protocol for morphogen-guided differentiation of brain cell types using human induced pluripotent stem cells. [PDF]

STAR Protoc
Qian L, Rosa JG, Tcw J.
europepmc   +1 more source

Unveiling the potential use of bioprinting materials in directing stem cell fate for cartilage regeneration: Focusing on induced pluripotent stem cells and enhanced lubrication (Review). [PDF]

Med Int (Lond)
Kaushalya GWN, Rajapakse S.
europepmc   +1 more source

A damaging mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells. [PDF]

Stem Cell Res Ther
Harissa Z, Bloks N, Steward N, Tufa SF, Keene DR, Ramos YFM, Meulenbelt I, Guilak F.   +7 more
europepmc   +1 more source

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Induced pluripotent stem cells

Russian Journal of Genetics, 2009
Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC).
A I, Shevchenko, S P, Medvedev, N A, Mazurok, S M, Zakiian   +3 more
openaire   +2 more sources

Induced Pluripotent Stem Cells

2010
Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an
Zaehres, Holm, Kim, Jeong Beom, Scholer, Hans R.   +2 more
openaire   +9 more sources