Results 21 to 30 of about 496,668 (364)
Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model. [PDF]
PLoS ONE, 2014 The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging.In a quinolinic acid-induced rat model of striatal ...
Shuhua Mu +8 more
doaj +1 more source
Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells
Stem Cells International, 2016 Rybp (Ring1 and Yy1 Binding Protein) is a transcriptional regulator and member of the noncanonical polycomb repressive complex 1 with essential role in early embryonic development.
Gergo Kovacs +2 more
doaj +1 more source
Stem Cell Research & Therapy, 2017 Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta +13 more
doaj +1 more source
Cryopreservation of Induced Pluripotent Stem Cells [PDF]
Cell Medicine, 2012 Induced pluripotent stem (iPS) cells have attracted attention as a promising cell source for medical treatment that could replace marrow stromal cells (MSCs) and adipose tissue-derived stem cells (ASCs). These pluripotent cells can be induced in vitro and in vivo to differentiate into various tissues and organs.
Hisashi Iwata +6 more
openaire +3 more sources
A village in a dish model system for population-scale hiPSC studies
Nature Communications, 2023 The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions.
Drew R. Neavin +20 more
doaj +1 more source
Using single-cell entropy to describe the dynamics of reprogramming and differentiation of induced pluripotent stem cells [PDF]
, 2020 Induced pluripotent stem cells (iPSCs) provide a great model to study the process of reprogramming and differentiation of stem cells. Single-cell RNA sequencing (scRNA-seq) enables us to investigate the reprogramming process at single-cell level. Here, we introduce single-cell entropy (scEntropy) as a macroscopic variable to quantify the cellular ...
arxiv +1 more source
International Journal of Molecular Sciences, 2018 Induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) serve as a unique source for cell therapy. We investigated whether exosomes from iMSCs promote the proliferation of human keratinocytes (HaCaT) and human dermal fibroblasts (HDFs)
Soo Kim +3 more
semanticscholar +1 more source
Mouse induced pluripotent stem cells
The International Journal of Developmental Biology, 2008 The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents a major breakthrough in stem cell research.
Geoghegan, Eamon, Byrnes, Lucy
openaire +5 more sources
Induced Pluripotent Stem Cells at Nanoscale [PDF]
Stem Cells and Development, 2010 Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been made possible with the expression of the transcription factor quartet Oct4, Sox2, c-Myc, and Klf4. Here, we compared iPS cells derived from mouse embryonic fibroblasts with the 4 factors to embryonic stem cells by electron microscopy.
Dagmar Zeuschner +3 more
openaire +3 more sources
Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]
PLoS ONE, 2014 In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo +13 more
doaj +1 more source