Results 31 to 40 of about 213,965 (187)

Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells

Stem Cells International, 2016
Rybp (Ring1 and Yy1 Binding Protein) is a transcriptional regulator and member of the noncanonical polycomb repressive complex 1 with essential role in early embryonic development.
Gergo Kovacs, Viktoria Szabo, Melinda K. Pirity   +2 more
doaj   +1 more source

Two sides of the same coin? Unraveling subtle differences between human embryonic and induced pluripotent stem cells by Raman spectroscopy

Stem Cell Research & Therapy, 2017
Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta, Maria Teresa De Angelis, Stefania Scalise, Patrizio Candeloro, Gianluca Santamaria, Mariagrazia Paonessa, Maria Laura Coluccio, Gerardo Perozziello, Stefania De Vitis, Antonella Sgura, Elisa Coluzzi, Vincenzo Mollace, Enzo Mario Di Fabrizio, Giovanni Cuda   +13 more
doaj   +1 more source

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

A village in a dish model system for population-scale hiPSC studies

Nature Communications, 2023
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions.
Drew R. Neavin, Angela M. Steinmann, Nona Farbehi, Han Sheng Chiu, Maciej S. Daniszewski, Himanshi Arora, Yasmin Bermudez, Cátia Moutinho, Chia-Ling Chan, Monique Bax, Mubarika Tyebally, Vikkitharan Gnanasambandapillai, Chuan E. Lam, Uyen Nguyen, Damián Hernández, Grace E. Lidgerwood, Robert M. Graham, Alex W. Hewitt, Alice Pébay, Nathan J. Palpant, Joseph E. Powell   +20 more
doaj   +1 more source

Pluripotency of Induced Pluripotent Stem Cells

Genomics, Proteomics & Bioinformatics, 2013
Abstract Induced pluripotent stem (iPS) cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years.
Feng, Chunjing, Jia, Yun-Dan, Zhao, Xiao-Yang   +2 more
openaire   +2 more sources

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]

PLoS ONE, 2014
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga   +13 more
doaj   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

Mouse induced pluripotent stem cells

The International Journal of Developmental Biology, 2008
The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents a major breakthrough in stem cell research.
Geoghegan, Eamon, Byrnes, Lucy
openaire   +4 more sources

Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model. [PDF]

PLoS ONE, 2014
The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging.In a quinolinic acid-induced rat model of striatal ...
Shuhua Mu, Jiachuan Wang, Guangqian Zhou, Wenda Peng, Zhendan He, Zhenfu Zhao, CuiPing Mo, Junle Qu, Jian Zhang   +8 more
doaj   +1 more source

Controlling the Bureaucracy of the Antipoverty Program [PDF]

, 1966
Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomaterial ...
Abounit, Armstrong, Auernheimer, Bae, Banito, Banito, Bao, Bass, Basu-Roy, Beier, Ben-Porath, Binyamin, Bitarte, Booth, Brand, Cantz, Cao, Case, Chappell, Chen, Chen, Chen, Chiou, Chylicki, Cobaleda, de Cremoux, Denishefsky, Dickinson, Doi, Eberhard, Egler, Eshghi, Esteban, Evans, Fagin, Feinstein, Feng, Feng, Fimia, Fusaki, Galli, Ghavami, Ghavami, Ghavami, Ghavami, Ghule, Girouard, Godar, Gore, Guo, Guo, Gustafsson, Hanada, Hanley, Hanna, Harper, Hauff, Hellebrekers, Hench, Hench, Hench, Hockemeyer, Hoffmeyer, Hong, Hotta, Hu, Huang, Jain, Jangamreddy, Jangamreddy, Jeter, Jia, Jia, Jia, Junttila, Kaji, Kang, Karimi-Busheri, Kawamura, Kharas, Kim, Kim, Kochhar, Kumar, Lafontan, Lee, Lefebvre, Lengerke, Li, Li, Liu, Liu, Maddika, Marchetto, Marion, Matsuoka, Matsuura, Menendez, Menendez, Mikkelsen, Miller, Miura, Mizuno, Moawad, Momcilovic, Mortensen, Nadiminty, Nagata, Nakagawa, Nakagawa, Nakatogawa, Neumann, Okita, Okita, Okita, Oliver, Parry, Patel, Peng, Place, Plews, Prigione, Ravikumar, Reya, Ribatti, Rius, Rotter, Rowland, Rubinsztein, Ruoslahti, Räisänen, Sabisz, Saigusa, Salemi, Sato, Schenke-Layland, Shan, Singh, Singh, Sommer, Sridharan, Stadtfeld, Stolzenburg, Suhr, Suo, Takahashi, Tirino, Tsai, Tsaousi, Uchino, Vafa, van den Berg, van Tuyn, Vazquez, Vessoni, Vierbuchen, Vincent, Viswanathan, Viswanathan, Wang, Warren, Wary, Wernig, West, Wiechec, Wiechec, Wilmut, Woltjen, Wu, Xynos, Yamanaka, Yang, Yoshida, Yoshimori, Yu, Zbinden, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou, Zreiqat   +184 more
core   +4 more sources