Results 21 to 30 of about 121,384 (261)

Induced Pluripotent Stem Cells at Nanoscale [PDF]

Stem Cells and Development, 2009
Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been made possible with the expression of the transcription factor quartet Oct4, Sox2, c-Myc, and Klf4. Here, we compared iPS cells derived from mouse embryonic fibroblasts with the 4 factors to embryonic stem cells by electron microscopy.
Dagmar, Zeuschner, Karina, Mildner, Holm, Zaehres, Hans R, Schöler   +3 more
openaire   +2 more sources

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]

PLoS ONE, 2014
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga   +13 more
doaj   +1 more source

Transgene Reactivation in Induced Pluripotent Stem Cell Derivatives and Reversion to Pluripotency of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells [PDF]

Stem Cells and Development, 2016
Induced pluripotent stem cells (iPSCs) have enormous potential in regenerative medicine and disease modeling. It is now felt that clinical trials should be performed with iPSCs derived with nonintegrative constructs. Numerous studies, however, including those describing disease models, are still being published using cells derived from iPSCs generated ...
Galat, Vasiliy, Galat, Yekaterina, Perepitchka, Mariana, Jennings, Lawrence J., Iannaccone, Philip M., Hendrix, Mary J.C.   +5 more
openaire   +2 more sources

Organoids in domestic animals: with which stem cells?

Veterinary Research, 2021
Organoids are three-dimensional structures that are derived from the self-organization of stem cells as they differentiate in vitro. The plasticity of stem cells is one of the major criteria for generating organoids most similar to the tissue structures ...
Bertrand Pain
doaj   +1 more source

Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming

Frontiers in Genetics, 2022
Pluripotency is a transient state in early embryos, which is regulated by an interconnected network of pluripotency-related genes. The pluripotent state itself seems to be highly dynamic, which leads to significant differences in the description of ...
Huajin Li, Huajin Li, Wenting Xu, Wenting Xu, Sijia Xiang, Sijia Xiang, Leiting Tao, Leiting Tao, Wen Fu, Wen Fu, Jinhui Liu, Jinhui Liu, Wenbin Liu, Wenbin Liu, Yamei Xiao, Yamei Xiao, Liangyue Peng, Liangyue Peng   +17 more
doaj   +1 more source

DIRECTED RE-PROGRAMMING OF SOMATIC CELLS: ADVANTAGES AND LIMITATIONS OF INDUCED PLURIPOTENT STEM CELLS (REVIEW)

Сибирский научный медицинский журнал, 2019
Stem cells are divided into embryonic and adult stem cells. The relevance of the use of stem cells in clinical practice has received new evidence in recent years however, the methods of obtaining stem cells for medical purposes cause ethical rejection ...
A. V. Korel, S. B. Kuznetsov
doaj   +1 more source

Mouse induced pluripotent stem cells

The International Journal of Developmental Biology, 2008
The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents a major breakthrough in stem cell research.
Geoghegan, Eamon, Byrnes, Lucy
openaire   +4 more sources

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source

A pathologist's perspective on induced pluripotent stem cells [PDF]

Laboratory Investigation, 2017
Induced pluripotent stem cell (iPSC) technology was originally developed in 2006. Essentially, it converts somatic cells into pluripotent stem cells by transiently expressing a few transcriptional factors. Once generated, these iPSCs can differentiate into all the cell types of our body, theoretically, which has attracted great attention for clinical ...
Noriko, Watanabe, Katherine E, Santostefano, Anthony T, Yachnis, Naohiro, Terada   +3 more
openaire   +2 more sources

Induced Pluripotent Stem Cells

Cell Transplantation, 2018
Many neurodegenerative diseases are progressive, complex diseases without clear mechanisms or effective treatments. To study the mechanisms underlying these diseases and to develop treatment strategies, a reliable in vitro modeling system is critical ...
Chia-Yu Chang, Hsiao-Chien Ting, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin   +6 more
doaj   +1 more source