Results 51 to 60 of about 496,668 (364)

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

Haematologica, 2010
Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne, Ladan Kobari, Christelle Mazurier, Philippe Tropel, Marie-Catherine Giarratana, Isabelle Zanella-Cleon, Laurent Kiger, Marie Wattenhofer-Donzé, Hélène Puccio, Nicolas Hebert, Alain Francina, Georges Andreu, Stéphane Viville, Luc Douay   +13 more
doaj   +1 more source

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

Nature Biomedical Engineering, 2018
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been exploited for the treatment of diseases.
Bohao Liu, Benjamin W. Lee, Koki Nakanishi, Aranzazu Villasante, Rebecca L. Williamson, Jordan B. Metz, Jinho Kim, Mariko Kanai, Lynn Bi, K. Brown, G. Di Paolo, S. Homma, P. Sims, V. Topkara, G. Vunjak‐Novakovic   +14 more
semanticscholar   +1 more source

Induced pluripotent stem cells in infections [PDF]

International Journal of Blood Transfusion and Immunohematology, 2015
Regenerative medicine has an exciting role in the treatment of disorders and conditions where there is an irreversible damage to a tissue or an organ or in immunodeficient state. Stem cells which have the potential to differentiate into specific types of cells, offers a new concept of regenerative medicine to treat spectrum of diseases including ...
Usha Bhoria, Anubha Singh, Deepak Kumar Singh   +2 more
openaire   +1 more source

Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia

Haematologica, 2014
Although β-thalassemia is one of the most common human genetic diseases, there is still no effective treatment other than bone marrow transplantation.
Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan Gong, Xinbing Guo, Zhaorui Ren, Fanyi Zeng   +7 more
doaj   +1 more source

The potential and limitations of induced pluripotent stem cells to achieve wound healing

Stem cell research & therapeutics, 2019
Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to dysregulation secondary to local and systemic
Jolanta Gorecka, Valentyna Kostiuk, A. Fereydooni, Luis Gonzalez, Jiesi Luo, Biraja C. Dash, T. Isaji, Shun Ono, Shirley Liu, Shin-Rong Lee, Jianbiao Xu, Jia Liu, R. Taniguchi, Bogdan Yastula, H. Hsia, Y. Qyang, A. Dardik   +16 more
semanticscholar   +1 more source

Induced pluripotent stem cells: An update [PDF]

International Journal of Blood Transfusion and Immunohematology, 2015
Introduction: The discovery that the mature cells can be reprogrammed to become pluripotent increased the enormous interest in induced pluripotent stem cell (iPSC) technology for their potential application in biomedical sciences. The breakthrough research offering induction of pluripotent status in somatic cells by direct reprogramming depends upon ...
Usha Bhoria, Deepak Kumar Singh, Anubha Singh   +2 more
openaire   +1 more source

DNA Methylation Is Involved in the Expression of miR-142-3p in Fibroblasts and Induced Pluripotent Stem Cells

Stem Cells International, 2014
MicroRNAs are differentially expressed in cells and regulate multiple biological processes. We have been analyzing comprehensive expression patterns of microRNA in human and mouse embryonic stem and induced pluripotent stem cells. We determined microRNAs
Siti Razila Abdul Razak, Yukihiro Baba, Hiromitsu Nakauchi, Makoto Otsu, Sumiko Watanabe   +4 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Downregulating EVA1C exerts the potential to promote neuron growth after neonatal hypoxic‐ischemic encephalopathy injury associated with alternative splicing

Ibrain, 2022
Neonatal hypoxic‐ischemic encephalopathy (NHIE) is one of the major diseases in newborns during the perinatal stage, which globally is the main reason for children's morbidity and mortality. However, the mechanism of NHIE still remains poorly clear.
Yue Hu, Rong Rong, Yi Wang, Shan‐Shan Yan, Su Liu, Lei Wang   +5 more
doaj   +1 more source

Structural maturation of myofilaments in engineered 3D cardiac microtissues characterized using small angle X-ray scattering [PDF]

arXiv, 2023
Understanding the structural and functional development of human-induced pluripotent stem-cell-derived cardiomyocytes is essential to engineering cardiac tissue that enables pharmaceutical testing, modeling diseases, and designing therapies. Here we use a method not commonly applied to biological materials, small angle X-ray scattering, to characterize
arxiv