Results 51 to 60 of about 398,685 (377)

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.

Physiological Reviews, 2019
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same genetic code as the zygote, and that activating parts of this code are sufficient to reprogram the cell to an early developmental state.
Peter Karagiannis, Kazutoshi Takahashi, M. Saito, Y. Yoshida, K. Okita, Akira Watanabe, H. Inoue, J. Yamashita, Masaya Todani, M. Nakagawa, M. Osawa, Yoshimi Yashiro, S. Yamanaka, K. Osafune   +13 more
semanticscholar   +1 more source

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source

DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]

PLoS ONE, 2012
The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo, Sailesh Gopalakrishna-Pillai, Stephanie L Nay, Sang-Won Park, Steven E Bates, Xianmin Zeng, Linda E Iverson, Timothy R O'Connor   +7 more
doaj   +1 more source

Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies

Neural Regeneration Research, 2022
Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected ...
Ignacio Rodriguez-Polo, Rüdiger Behr
doaj   +1 more source

Induced Pluripotent Stem Cells

Cell Transplantation, 2018
Many neurodegenerative diseases are progressive, complex diseases without clear mechanisms or effective treatments. To study the mechanisms underlying these diseases and to develop treatment strategies, a reliable in vitro modeling system is critical ...
Chia-Yu Chang, Hsiao-Chien Ting, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin   +6 more
doaj   +1 more source

A pathologist's perspective on induced pluripotent stem cells [PDF]

Laboratory Investigation, 2017
Induced pluripotent stem cell (iPSC) technology was originally developed in 2006. Essentially, it converts somatic cells into pluripotent stem cells by transiently expressing a few transcriptional factors. Once generated, these iPSCs can differentiate into all the cell types of our body, theoretically, which has attracted great attention for clinical ...
Noriko Watanabe, Anthony T. Yachnis, Naohiro Terada, Katherine E. Santostefano   +3 more
openaire   +3 more sources

Controlling the Bureaucracy of the Antipoverty Program [PDF]

, 1966
Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomaterial ...
Abounit, Armstrong, Auernheimer, Bae, Banito, Banito, Bao, Bass, Basu-Roy, Beier, Ben-Porath, Binyamin, Bitarte, Booth, Brand, Cantz, Cao, Case, Chappell, Chen, Chen, Chen, Chiou, Chylicki, Cobaleda, de Cremoux, Denishefsky, Dickinson, Doi, Eberhard, Egler, Eshghi, Esteban, Evans, Fagin, Feinstein, Feng, Feng, Fimia, Fusaki, Galli, Ghavami, Ghavami, Ghavami, Ghavami, Ghule, Girouard, Godar, Gore, Guo, Guo, Gustafsson, Hanada, Hanley, Hanna, Harper, Hauff, Hellebrekers, Hench, Hench, Hench, Hockemeyer, Hoffmeyer, Hong, Hotta, Hu, Huang, Jain, Jangamreddy, Jangamreddy, Jeter, Jia, Jia, Jia, Junttila, Kaji, Kang, Karimi-Busheri, Kawamura, Kharas, Kim, Kim, Kochhar, Kumar, Lafontan, Lee, Lefebvre, Lengerke, Li, Li, Liu, Liu, Maddika, Marchetto, Marion, Matsuoka, Matsuura, Menendez, Menendez, Mikkelsen, Miller, Miura, Mizuno, Moawad, Momcilovic, Mortensen, Nadiminty, Nagata, Nakagawa, Nakagawa, Nakatogawa, Neumann, Okita, Okita, Okita, Oliver, Parry, Patel, Peng, Place, Plews, Prigione, Ravikumar, Reya, Ribatti, Rius, Rotter, Rowland, Rubinsztein, Ruoslahti, Räisänen, Sabisz, Saigusa, Salemi, Sato, Schenke-Layland, Shan, Singh, Singh, Sommer, Sridharan, Stadtfeld, Stolzenburg, Suhr, Suo, Takahashi, Tirino, Tsai, Tsaousi, Uchino, Vafa, van den Berg, van Tuyn, Vazquez, Vessoni, Vierbuchen, Vincent, Viswanathan, Viswanathan, Wang, Warren, Wary, Wernig, West, Wiechec, Wiechec, Wilmut, Woltjen, Wu, Xynos, Yamanaka, Yang, Yoshida, Yoshimori, Yu, Zbinden, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou, Zreiqat   +184 more
core   +4 more sources

Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations

Stem cell research & therapeutics, 2019
Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not exist naturally and are instead generated (“induced” or “reprogrammed”) in culture from ...
S. Moradi, H. Mahdizadeh, T. Šarić, Johnny Kim, J. Harati, Hosein Shahsavarani, B. Greber, Joseph B. Moore   +7 more
semanticscholar   +1 more source

Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity

SAGE Open Medicine, 2020
Objectives: To establish a straightforward single-cell passaging cultivation method that enables high-quality maintenance of human induced pluripotent stem cells without the appearance of karyotypic abnormalities or loss of pluripotency.
Estela Cruvinel, Isabella Ogusuku, Rosanna Cerioni, Sirlene Rodrigues, Jéssica Gonçalves, Maria Elisa Góes, Juliana Morais Alvim, Anderson Carlos Silva, Vanesca de Souza Lino, Enrique Boccardo, Ernesto Goulart, Alexandre Pereira, Rafael Dariolli, Marcos Valadares, Diogo Biagi   +14 more
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Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Nature, 2012
Our understanding of Alzheimer’s disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.
Mason A. Israel, Shauna H. Yuan, C. Bardy, Sol M. Reyna, Yangling Mu, C. Herrera, M. Hefferan, S. van Gorp, Kristopher L. Nazor, F. Boscolo, C. Carson, L. Laurent, M. Marsala, F. Gage, A. Remes, E. Koo, L. Goldstein   +16 more
semanticscholar   +1 more source