Results 41 to 50 of about 4,786,356 (294)

CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]

, 2013
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen, Gentile, M, Cantaert, T, Tineke Cantaert, Menard, L, Laurence Menard, Morbach, H, Saadoun, D, Virdee, M, Neil Romberg, Kinnunen, T, Maurizio Gentile, Rachid, R, Martinez-Pomar, N, Geha, R, Henner Morbach, Matamoros, N, Cunningham-Rundles, C, Nicolas Chamberlain, Nuria Matamoros, Andrea Cerutti, Yen Shing Ng, Bodo Grimbacher, Natalia Martinez-Pomar, Meffre, E, Eric Meffre, David Saadoun, Manmeet Virdee, Rima Rachid, Cerutti, A, Raif Geha, Romberg, N, Brimbacher, B, Chamberlain, N, Charlotte Cunningham-Rundles, Ng, YS   +35 more
core   +1 more source

Climate change impacts and holobiome-guided microbial strategies for abiotic stress mitigation in strawberry cultivation

Frontiers in Agronomy
Strawberry (Fragaria × ananassa), with global production exceeding 9.8 million tons and a market value of USD 19 billion, is a major horticultural crop increasingly threatened by climate change.
Jin-Soo Son, Su Yeon Lee, Mee Kyung Sang, Choong-Min Ryu, Choong-Min Ryu, Francesco Spinelli   +5 more
doaj   +1 more source

The price of tumor control [PDF]

, 2013
Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients.
Berking, Carola, Bockmeyer, Clemens L., Voskens, Caroline J., Fluck, Michael, Heinzerling, Lucie M., Schuler, Gerold, Vaubel, Julia, Keller, Ullrich, Goldinger, Simone M., Wilhelm, Tabea, Moos, Roger von, Mohr, Peter, Eigentler, Thomas, Paetzold, Sylvie, Justich, Armin, Hundorfean, Gheorghe, Hauschild, Axel, Mateus, Christine, Klein, Christina, Loquai, Carmen, Schadendorf, Dirk, Göppner, Daniela, Robert, Caroline, Bergmann, Tanja, Gutzmer, Ralf, Hein, Rüdiger, Grabbe, Stephan, Dummer, Reinhard, Kaehler, Katharina C., Trefzer, Uwe, Ulrich, Jens, Weder, Patrik, Schuler-Thurner, Beatrice, Garbe, Claus, Satzger, Imke, Schlaeppi, Marc   +35 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Unravelling salt stress tolerance: physiological, morphological and genetic components in crop species and model plants [PDF]

, 2008
This PhD Thesis address fundamental mechanisms of salt stress response in plants from an agronomic, physiological, morphological and genetic point of view. Specifically we considered salt stress tolerance performances of eleven wild species of Cruciferae,
Orsini, Francesco
core   +1 more source

CD4-blockade can induce protection from peanut-induced anaphylaxis

Frontiers in Immunology, 2011
Monoclonal antibodies (mAb) have been shown effective in inducing immune tolerance in a range of animal models of autoimmunity, allergy, and transplantation.
Joana eDuarte, Marta eCaridade, Luis eGraca, Luis eGraca   +3 more
doaj   +1 more source

Type V collagen induced tolerance suppresses collagen deposition, TGF-β and associated transcripts in pulmonary fibrosis. [PDF]

PLoS ONE, 2013
RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and matrix deposition. Recent reports highlight an autoimmune component in IPF pathogenesis. We have reported anti-col(V) immunity in
Ragini Vittal, Elizabeth A Mickler, Amanda J Fisher, Chen Zhang, Katia Rothhaar, Hongmei Gu, Krista M Brown, Amir Emtiazjoo, Jeremy M Lott, Sarah B Frye, Gerald N Smith, George E Sandusky, Oscar W Cummings, David S Wilkes   +13 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Fetal inflammation induces acute immune tolerance in the neonatal rat hippocampus

Journal of Neuroinflammation, 2021
Background Infants born preterm due to chorioamnionitis are frequently affected by a fetal inflammatory response syndrome (FIRS) and then by subsequent postnatal infections. FIRS and postnatal systemic inflammatory events independently contribute to poor
Garima Singh, Bradley J. Segura, Michael K. Georgieff, Tate Gisslen   +3 more
doaj   +1 more source