Innate Immune Tolerance in Microglia Does Not Impact on Central Nervous System Prion Disease
Frontiers in Cellular Neuroscience, 2022 Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep, are infectious and chronic neurodegenerative diseases to which there are no cures.
Reiss Pal +2 more
doaj +1 more source
Activity Based Tolerance Allocation (ABTA) – Driving tolerance synthesis by evaluating its global cost [PDF]
, 2009 This paper deals with tolerance allocation driven by an activity based approach. Its main objective is to rationally give a good indicator of the relevance of tolerances values fixed by designers.
MARTIN, Patrick +3 more
core +1 more source
Frontiers in Pharmacology, 2022 Opioid tolerance, opioid-induced hyperalgesia during repeated opioid administration, and chronic pain are associated with upregulation of adenylyl cyclase activity.
Kayla Johnson +8 more
doaj +1 more source
Human rhinovirus infection induces local and systemic immunological tolerance in healthy volunteers [PDF]
Intensive Care Medicine Experimental, 2015 A large proportion of ICU patients suffer from respiratory virus infections. This is often complicated by secondary infections, suggesting increased vulnerability in these patients. Recent work has shown that in bacterial sepsis, a immunosuppressive state called “immunoparalysis” accounts for this increased vulnerability.
Koch, RM +7 more
openaire +1 more source
Epicutaneous immunization with type II collagen inhibits both onset and progression of chronic collagen-induced arthritis. [PDF]
, 2007 Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias.
Strobel, S +9 more
core +2 more sources
Research in Plant Disease, 2017 Recently, global warming and drastic climate change are the greatest threat to the world. The climate change can affect plant productivity by reducing plant adaptation to diverse environments including frequent high temperature; worsen drought condition ...
Sung-Je Yoo, Mee Kyung Sang
doaj +3 more sources
The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance. [PDF]
PLoS Biology, 2006 Overlapping roles have been ascribed for T cell anergy, clonal deletion, and regulation in the maintenance of peripheral immunological tolerance. A measurement of the individual and additive impacts of each of these processes on systemic tolerance is ...
Nevil J Singh +2 more
doaj +1 more source
The Role of Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy
Frontiers in Immunology, 2021 In recent decades, a rapid increase in the prevalence of food allergies has led to extensive research on novel treatment strategies and their mechanisms.
Guirong Liu +4 more
doaj +1 more source
Sertoli Cells Induce Systemic Donor-Specific Tolerance in Xenogenic Transplantation Model [PDF]
Cell Transplantation, 2006 Cell therapy is a potentially powerful tool in the treatment of many grave disorders including leukemia, immune deficiencies, autoimmune diseases, and diabetes. However, finding matched donors is challenging and recipients may suffer from the severe complications of systemic immune suppression.
R. Shamekh +5 more
openaire +3 more sources
Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic) [PDF]
, 2012 Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation.
Qureshi, A.J. +9 more
core +1 more source