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Infectious Spleen and Kidney Necrosis Virus Triggers Ferroptosis in CPB Cells to Enhance Virus Replication [PDF]

Viruses
The role of ferroptosis—a novel iron-dependent programmed cell death pathway—in infectious spleen and kidney necrosis virus (ISKNV) infection remains poorly understood. Here, we demonstrate that ISKNV infection induces ferroptosis in CPB cells. Following
Qiushuang Zhang, Ouqin Chang, Qiang Lin, Hongru Liang, Yinjie Niu, Xia Luo, Baofu Ma, Ningqiu Li, Xiaozhe Fu   +8 more
doaj   +3 more sources

Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements [PDF]

Virulence, 2022
Hypoxia frequently occurs in aquatic environments, especially in aquaculture areas. However, research on the relationship between hypoxic aquatic environments with viral diseases outbreak is limited, and its underlying mechanisms remain elusive.
Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo He   +6 more
doaj   +4 more sources

Asparagine Availability Is a Critical Limiting Factor for Infectious Spleen and Kidney Necrosis Virus Replication [PDF]

Viruses
Infectious spleen and kidney necrosis virus (ISKNV) has brought huge economic loss to the aquaculture industry. Through interfering with the viral replication and proliferation process that depends on host cells, its pathogenicity can be effectively ...
Baofu Ma, Fangying Li, Xiaozhe Fu, Xia Luo, Qiang Lin, Hongru Liang, Yinjie Niu, Ningqiu Li   +7 more
doaj   +4 more sources

Transcriptomic Analysis of the Spleen from Asian Seabass (Lates calcarifer) Infected with Infectious Spleen and Kidney Necrosis Virus [PDF]

Viruses
Infectious spleen and kidney necrosis virus (ISKNV) is an emerging viral pathogen with an expanding host range, posing a significant threat to economically important fish species.
Hong-Yi Xin, Lim Xin Ying, Lee Ching Pei Carmen, Mookkan Prabakaran   +3 more
doaj   +3 more sources

Prevalence of Infectious Spleen and Kidney Necrosis Virus (ISKNV), Nervous Necrosis Virus (NNV) and Ectoparasites in Juvenile Epinephelus spp. Farmed in Aceh, Indonesia [PDF]

Pathogens, 2020
A cross-sectional survey was used to estimate the prevalence of infections with the Infectious spleen and kidney necrosis virus (ISKNV, Megalocytivirus), nervous necrosis virus (NNV, Betanodavirus), and infestations with ectoparasites during the rainy ...
Bakhtiar Sah Putra, Paul M. Hick, Evelyn Hall, Richard J. Whittington, Razi Khairul, Evarianti, Nurbariah, Joy A. Becker   +7 more
doaj   +5 more sources

Molecular mechanism of infectious spleen and kidney necrosis virus in manipulating the hypoxia-inducible factor pathway to augment virus replication [PDF]

Virulence
Infectious spleen and kidney necrosis virus (ISKNV), a member of the genus Megalocytivirus in the family Iridoviridae, can infect over 50 fish species and cause significant economic losses in Asia.
Jian He, Yang Yu, Wenhui Liu, Zhimin Li, Zhang Qi, Shaoping Weng, Changjun Guo, Jianguo He   +7 more
doaj   +4 more sources

Genotypic Characterization of <i>Infectious Spleen and Kidney Necrosis Virus</i> (ISKNV) in Southeast Asian Aquaculture. [PDF]

Transbound Emerg Dis, 2023
Infectious spleen and kidney necrosis virus (ISKNV) is a species within the genus Megalocytivirus (family Iridoviridae), which causes high mortality disease in many freshwater and marine fish species. ISKNV was first reported in Asia and is an emerging threat to aquaculture with increasing global distribution, in part due to its presence in ornamental ...
Fusianto CK, Becker JA, Subramaniam K, Whittington RJ, Koda SA, Waltzek TB, Murwantoko, Hick PM.   +7 more
europepmc   +3 more sources

A Multiplexed, Tiled PCR Method for Rapid Whole-Genome Sequencing of Infectious Spleen and Kidney Necrosis Virus (ISKNV) in Tilapia [PDF]

Viruses, 2023
Tilapia farming is one of the most important sectors in aquaculture worldwide and of major importance to global food security. Infectious spleen and kidney necrosis virus (ISKNV) has been identified as an agent of high morbidity and mortality ...
Shayma Alathari, Dominique L. Chaput, Luis M. Bolaños, Andrew Joseph, Victoria L. N. Jackson, David Verner-Jeffreys, Richard Paley, Charles R. Tyler, Ben Temperton   +8 more
doaj   +2 more sources

Development of Duplex Loop-Mediated Isothermal Amplification with Hydroxynaphthol Blue for Detection of Infectious Spleen and Kidney Necrosis Virus and Aeromonas hydrophila in Chinese Perch (Siniperca chuatsi) [PDF]

Microorganisms
Bacterial sepsis caused by Aeromonas hydrophila (A. hydrophila) and infectious spleen and kidney necrosis virus disease (ISKNVD) caused by infectious spleen and kidney necrosis virus (ISKNV) frequently result in significant mortality among Chinese perch (
Xiao He, Jingyi Wu, Xu Tan, Sunan Xu, Weiguang Kong, Xiaodan Liu   +5 more
doaj   +2 more sources

Partial validation of a TaqMan quantitative polymerase chain reaction for the detection of the three genotypes of Infectious spleen and kidney necrosis virus. [PDF]

PLoS ONE, 2023
Megalocytiviruses (MCVs) are double-stranded DNA viruses known to infect important freshwater and marine fish species in the aquaculture, food, and ornamental fish industries worldwide.
Samantha A Koda, Kuttichantran Subramaniam, Paul M Hick, Evelyn Hall, Thomas B Waltzek, Joy A Becker   +5 more
doaj   +3 more sources