Aging Cell, Volume 25, Issue 6, June 2026.Aging skews pulmonary myeloid responses during acute SARS‐CoV‐2 infection toward severe disease. Disease progression is characterized by excessive lung neutrophil accumulation together with impaired activation of classical monocytes, including a defect in PD‐L1 upregulation.
Serban Morosan +20 more
wiley +1 more source
Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging
Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka +4 more
wiley +1 more source
Inflammaging and Midlife Women: Translating Geroscience into Clinical Practice. [PDF]
J Midlife HealthMunshi A, Garg R.
europepmc +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup +1 more
wiley +1 more source
Diet and Exercise Interventions in Pediatric Cancer Survivors and Effects on Cardiometabolic Disease Risk and Inflammaging Biomarkers: A Systematic Review. [PDF]
Adv NutrCares K +5 more
europepmc +1 more source
The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley +1 more source
Blood-Based Inflammatory and Metabolic Biomarkers for Assessing Symptom Burden and Quality of Life in Older Adults with Cancer: A Narrative Review. [PDF]
Ther Clin Risk ManagLu L, Zhang Y.
europepmc +1 more source
The aging paradox of Cushing's syndrome: Stress without clear senescence?
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira +1 more
wiley +1 more source
Rosemary Aqueous Extract as a Natural Alternative to Retinol for Skin Aging Intervention. [PDF]
Pharmaceuticals (Basel)Gao P, Zhang H, Gu X.
europepmc +1 more source
The evidence for old age motor neuron death: A scoping review
Physiological Reports, Volume 14, Issue 11, June 2026.We systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Sang Won Cheung, Matthew J. Fogarty
wiley +1 more source