Results 171 to 180 of about 15,244 (279)

Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in Psoriasis - A Narrative Review of Potential Mechanisms and Anti-Inflammaging Strategies. [PDF]

Psoriasis (Auckl)
Filipek K, Nowowiejska-Purpurowicz J, Flisiak I.   +2 more
europepmc   +1 more source

Vascular Immune Remodeling: A CD4+ T Cell–Driven Immune Trajectory Associated With Arterial Stiffness

Aging Cell, Volume 25, Issue 6, June 2026.
This study integrated arterial stiffness with peripheral TCRβ repertoire and single‐cell transcriptomics in adults without cardiovascular disease, revealing a CD4+ T cell–driven “vascular immune remodeling” trajectory distinct from classical immunosenescence: increased TCR diversity, broad expansion of low‐frequency public clones and virus‐associated ...
Yu Miao, Bangwei Chen, Changqing Zeng, Xiaofen Wu, Minglei Yang, Cuntai Zhang, Jianguo Zhang, Yutao Du, Tao Li, Lei Ruan   +9 more
wiley   +1 more source

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications. [PDF]

Cells
Bertoni G, Ristori S, Monti D.
europepmc   +1 more source

Osteoimmunologic and Immune-Aging Signatures in Postmenopausal Women with Periodontitis and Low Bone Mineral Density: A Cross-Sectional Study. [PDF]

Diagnostics (Basel)
Sufaru IG, Martu MA, Laza MG, Solomon SM, Luchian I, Pasarin L, Tatarciuc D, Martu I.   +7 more
europepmc   +1 more source

Nuclear Enlargement as a Histological Hallmark of Skeletal Muscle Aging, Revealed by Deep Learning‐Driven Analysis and Validated in Inflammatory Myopathies

Aging Cell, Volume 25, Issue 6, June 2026.
Deep learning–based analysis of human skeletal muscle histology identifies increased nuclear size and altered nuclear number as robust features of aging. These morphometric changes associate with coordinated transcriptional programs and support a scalable, tissue‐level biomarker framework for muscle aging, validated in inflammatory myopathy cohorts ...
Tam Dao, Thanh T. Nguyen, Gia Minh Hoang, Junhyeon Park, Yunju Jo, Thach Hoang Ngoc, Diep Hong Pho, Dien Tran Minh, Emma Anh Ton, Sunjae Lee, Hyun Jin Kim, Vu Chi Dung, Jae Gwan Kim, Dongryeol Ryu   +13 more
wiley   +1 more source

The quantified immune-aging dysregulation index: a large-language model-powered method for annotating and quantifying systems-level dysregulation. [PDF]

Front Artif Intell
Vavougios GD, Hadjigeorgiou G.
europepmc   +1 more source

Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging

Aging Cell, Volume 25, Issue 6, June 2026.
This review positions magnesium as a central bioenergetic checkpoint that orchestrates mitochondrial function and metabolic resilience. By defining the functional ATP pool and stabilizing mitochondrial performance, magnesium homeostasis serves as a mechanistic link between renal handling, metabolic disease, and the aging process.
Chien‐Wei Huang, Chen‐Yueh Wen, Andy P. Tsai, Boyang Wang, Kuan‐Hao Tsui, Yu‐Juei Hsu, Chia‐Jung Li   +6 more
wiley   +1 more source

Urbanization, environment, and inflammaging: insights from sub-Saharan Africa. [PDF]

NPJ Aging
Bickler SW, Cossa M, Mendes de Sousa I, Noormahomed EV.   +3 more
europepmc   +1 more source

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

Ultra-Processed Foods and Chronic Kidney Disease: Is Inflammaging the Missing Link? [PDF]

Biomolecules
Kounatidis DC, Evangelopoulos A, Dimitriou K, Vallianou NG.   +3 more
europepmc   +1 more source