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Inflammaging and ‘Garb-aging’ [PDF]
Trends in Endocrinology and Metabolism, 2017 'Inflammaging' refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-
Miriam Capri +2 more
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Inflammaging: mechanisms and role in the cardiac and vasculature
Trends in Endocrinology and Metabolism, 2023 Aging triggers a wide range of cellular and molecular aberrations in the body, giving rise to inflammation and associated diseases. In particular, aging is associated with persistent low-grade inflammation even in absence of inflammatory stimuli, a ...
Claudio Franceschi +2 more
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Ageing Research Reviews, 2021
Aging is a complex phenomenon associated with a wide spectrum of physical and physiological changes affecting every part of all metazoans, if they escape death prior to reaching maturity. Critical to survival, the immune system evolved as the principal component of response to injury and defense against pathogen invasions.
Babak, Baban +8 more
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Aging is a complex phenomenon associated with a wide spectrum of physical and physiological changes affecting every part of all metazoans, if they escape death prior to reaching maturity. Critical to survival, the immune system evolved as the principal component of response to injury and defense against pathogen invasions.
Babak, Baban +8 more
openaire +2 more sources
Journal of Investigative Dermatology, 2021
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed
Suzanne M. Pilkington +3 more
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As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed
Suzanne M. Pilkington +3 more
openaire +2 more sources
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Archivum Immunologiae Et Therapiae Experimentalis, 2015Longevity and aging are two sides of the same coin, as they both derive from the interaction between genetic and environmental factors. Aging is a complex, dynamic biological process characterized by continuous remodeling. One of the most recent theories on aging focuses on immune response, and takes into consideration the activation of subclinical ...
Giuseppe Maltese +2 more
exaly +5 more sources
The role of nutrition in inflammaging
Ageing Research Reviews, 2022Old age is characterized by a peculiar low-grade, chronic, and "sterile" inflammatory state, which has been termed "inflammaging." This is believed to substantially contribute to the pathogenesis of many age-related diseases and to the progression of the ageing process. An adequate nutritional status is of great importance for maintaining proper immune
Paolo, Di Giosia +5 more
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Gerontology, 2019
Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated ...
Fulop, Tamas +2 more
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Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated ...
Fulop, Tamas +2 more
openaire +2 more sources
MDSCs, ageing and inflammageing
Cellular Immunology, 2021The challenge of distinguishing between changes attributable to ageing and those attributable to pathology is even greater for the immune system than for many other organs, and this is especially true for myeloid-derived suppressor cells (MDSCs). Hematopoiesis is different in older adults with a bias towards myelopoiesis, and older adults also manifest
Graham, Pawelec +4 more
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Current Opinion in Clinical Nutrition & Metabolic Care, 2017
Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes.This review ...
Ursula, Müller-Werdan +2 more
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Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes.This review ...
Ursula, Müller-Werdan +2 more
openaire +2 more sources
Neurovascular Inflammaging in Health and Disease [PDF]
Cells, 2020 Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of ...
Adam Nyúl-Tóth +2 more
exaly +6 more sources