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Inflammaging and ‘Garb-aging’ [PDF]
Trends in Endocrinology and Metabolism, 2017 'Inflammaging' refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-
Claudio Franceschi +2 more
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Inflammaging and Osteoarthritis
Clinical Reviews in Allergy & Immunology, 2022Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in the past it was considered a mere consequence of cartilage degradation leading to anatomical and functional joint impairment, in recent decades, there has been a more dynamic view with the synovium, the cartilage, and the subchondral bone ...
F. Motta +3 more
semanticscholar +3 more sources
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Archivum Immunologiae Et Therapiae Experimentalis, 2015 Longevity and aging are two sides of the same coin, as they both derive from the interaction between genetic and environmental factors. Aging is a complex, dynamic biological process characterized by continuous remodeling. One of the most recent theories
Paola Lucia Minciullo +2 more
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Immunology of Aging: the Birth of Inflammaging [PDF]
Clinical Reviews in Allergy and Immunology, 2021 The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress.
Tamás Fülöp +2 more
exaly +4 more sources
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2014 Claudio Franceschi +2 more
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Inflammaging: mechanisms and role in the cardiac and vasculature
Trends in Endocrinology and Metabolism, 2023 Aging triggers a wide range of cellular and molecular aberrations in the body, giving rise to inflammation and associated diseases. In particular, aging is associated with persistent low-grade inflammation even in absence of inflammatory stimuli, a ...
Amir Ajoolabady +2 more
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The role of nutrition in inflammaging
Ageing Research Reviews, 2022Old age is characterized by a peculiar low-grade, chronic, and "sterile" inflammatory state, which has been termed "inflammaging." This is believed to substantially contribute to the pathogenesis of many age-related diseases and to the progression of the ageing process. An adequate nutritional status is of great importance for maintaining proper immune
Paolo Giorgini +2 more
exaly +3 more sources