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The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
Frontiers in AgingAs we age, our immune system’s ability to effectively respond to pathogens declines, a phenomenon known as immunosenescence. This age-related deterioration affects both innate and adaptive immunity, compromising immune function and leading to chronic ...
Matthew J Yousefzadeh
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Immunosenescence and Inflammaging: Mechanisms and Role in Diseases.
Ageing Research ReviewsAge-related changes initiate a cascade of cellular and molecular alterations that lead to immune system dysfunction or abnormal activation, predisposing individuals to age-related diseases.
Amir Ajoolabady +5 more
semanticscholar +1 more source
Biomolecules
Cardiovascular aging is a multifactorial and systemic process that contributes significantly to the global burden of cardiovascular disease, particularly in older populations.
Ewelina Młynarska +9 more
semanticscholar +1 more source
Cardiovascular aging is a multifactorial and systemic process that contributes significantly to the global burden of cardiovascular disease, particularly in older populations.
Ewelina Młynarska +9 more
semanticscholar +1 more source
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans [PDF]
Mechanisms of Ageing and Development, 2007 A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging.Within this
Claudio Franceschi +2 more
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Suppression of thrombospondin-1-mediated inflammaging prolongs hematopoietic healthspan
Science immunologyChronic low-grade inflammation observed in older adults, termed inflammaging, is a common feature underlying a multitude of aging-associated maladies including a decline in hematopoietic activity. However, whether suppression of inflammaging can preserve
Pradeep Ramalingam +10 more
semanticscholar +1 more source
Age-related bone diseases: Role of inflammaging.
Journal of AutoimmunityBone aging is characterized by an imbalance in the physiological and pathological processes of osteogenesis, osteoclastogenesis, adipogenesis, and chondrogenesis, resulting in exacerbated bone loss and the development of age-related bone diseases ...
Jiaming Bi +9 more
semanticscholar +1 more source
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Science immunologyHealthy aging relies on a symbiotic host–microbiota relationship. The age-associated decline of the immune system can pose a threat in this delicate equilibrium.
M. M. Gómez de las Heras +17 more
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Nihon rinsho. Japanese journal of clinical medicine, 2019
Chronic inflammation is the common pathological basis for age-associated diseases. Chronic activation of basic inflammatory sates is known to associate with aging. Changes in immune system (immunosenescence), tissue microenvironment, such as the accumulation of cell debris, and systemic changes in metabolic and hormonal signals, likely contribute to ...
Yumiko, Oishi, Ichiro, Manabe
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Chronic inflammation is the common pathological basis for age-associated diseases. Chronic activation of basic inflammatory sates is known to associate with aging. Changes in immune system (immunosenescence), tissue microenvironment, such as the accumulation of cell debris, and systemic changes in metabolic and hormonal signals, likely contribute to ...
Yumiko, Oishi, Ichiro, Manabe
openaire +1 more source
Dasatinib and Quercetin Mitigate Age‐Related Alveolar Bone Inflammaging and Neutrophil Infiltration
Oral DiseasesAge‐related alveolar bone resorption poses a major dental health challenge, yet its mechanisms and treatments are poorly understood. This study investigates the impact of dasatinib and quercetin (D + Q) treatment on senescent cells (SnCs), senescence ...
Jinru Tang +11 more
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International Journal of Molecular Sciences
Immunosenescence refers to the set of immunoendocrinological alterations underlying the progressive decline in innate and adaptive immune function that occurs with aging.
E. Aitella +4 more
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Immunosenescence refers to the set of immunoendocrinological alterations underlying the progressive decline in innate and adaptive immune function that occurs with aging.
E. Aitella +4 more
semanticscholar +1 more source