Results 231 to 240 of about 15,244 (279)
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Ageing Research Reviews, 2021
Aging is a complex phenomenon associated with a wide spectrum of physical and physiological changes affecting every part of all metazoans, if they escape death prior to reaching maturity. Critical to survival, the immune system evolved as the principal component of response to injury and defense against pathogen invasions.
Babak, Baban +8 more
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Aging is a complex phenomenon associated with a wide spectrum of physical and physiological changes affecting every part of all metazoans, if they escape death prior to reaching maturity. Critical to survival, the immune system evolved as the principal component of response to injury and defense against pathogen invasions.
Babak, Baban +8 more
openaire +2 more sources
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Ageing Research Reviews, 2021 Aurelia Santoro +2 more
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Journal of Investigative Dermatology, 2021
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed
Suzanne M. Pilkington +3 more
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As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed
Suzanne M. Pilkington +3 more
openaire +2 more sources
MDSCs, ageing and inflammageing
Cellular Immunology, 2021The challenge of distinguishing between changes attributable to ageing and those attributable to pathology is even greater for the immune system than for many other organs, and this is especially true for myeloid-derived suppressor cells (MDSCs). Hematopoiesis is different in older adults with a bias towards myelopoiesis, and older adults also manifest
Graham, Pawelec +4 more
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The Nrf2-HO-1 system and inflammaging
Frontiers in ImmunologyNrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1 ...
Sinéad A O'Rourke +2 more
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Gerontology, 2019
Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated ...
Tamàs, Fülöp +2 more
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Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated ...
Tamàs, Fülöp +2 more
openaire +2 more sources
Inflammaging and human longevity in the omics era
Mechanisms of Ageing and Development, 2017 Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged.
Daniela Monti +2 more
exaly +2 more sources
Current Opinion in Clinical Nutrition & Metabolic Care, 2017
Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes.This review ...
Ursula, Müller-Werdan +2 more
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Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes.This review ...
Ursula, Müller-Werdan +2 more
openaire +2 more sources
Bladder cancer, inflammageing and microbiomes
Nature Reviews Urology, 2022Ageing is correlated with elevated bladder cancer incidence, morbidity and mortality. Advanced age is also associated with elevated markers of chronic inflammation and perturbations in gut and urinary tract microbiota. One reason for the increased incidence and mortality of bladder cancer in the elderly might be that age-associated changes in multiple ...
Martin, Austin +4 more
openaire +3 more sources
Targeting immunosenescence and inflammaging: advancing longevity research
Experimental and Molecular MedicineHere we examine the crucial role of the immune system in aging, with a particular focus on two interconnected processes: immunosenescence and inflammaging, which contribute to age-related decline. Our goal is to provide a thorough overview of the various
Thi Quynh Trang Nguyen, Kyung A Cho
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