Results 251 to 260 of about 15,244 (279)

Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice

Microbiome
Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla.
F. Sommer, J. P. Bernardes, Lena Best, N. Sommer, J. Hamm, B. Messner, V. López-Agudelo, A. Fazio, Georgios Marinos, A. S. Kadibalban, G. Ito, M. Falk-Paulsen, Christoph Kaleta, P. Rosenstiel   +13 more
semanticscholar   +1 more source

A SPARC-ling link to inflammaging

Science Immunology, 2022
Adipocyte derived SPARC induces pro-inflammatory changes to macrophages, leading to aging that can be reduced by caloric restriction.
openaire   +2 more sources

Epigenetic clocks and inflammaging: pitfalls caused by ignoring cell-type heterogeneity

bioRxiv
Epigenetic clocks are machine learning predictors of chronological age that have consistently been shown to be also informative of biological age measures, such as all-cause mortality. A recent study has argued against the use of machine learning methods
Xiaolong Guo, Andrew E. Teschendorff
semanticscholar   +1 more source

A receptor for glycation end products (RAGE) is a key transmitter between garb-aging and inflammaging.

Ageing Research Reviews
A receptor for glycation end products (RAGE) plays a key role in the pathogenesis of many chronic diseases associated with aging. Acting as a multi-ligand sensor, RAGE is able to bind a wide range of stimuli, which fuels inflammation. This makes it a key
Zulfiia G Guvatova, A. Vakhrusheva, A. Moskalev   +2 more
semanticscholar   +1 more source

Nucleoside reverse transcriptase inhibitors as a therapeutic opportunity to counteract inflammaging and age-related diseases: New evidence from epidemiological data.

Ageing Research Reviews
Nucleoside Reverse Transcriptase Inhibitors (NRTIs), widely used to treat HIV and hepatitis B, have recently been shown to possess anti-inflammatory properties by inhibiting inflammasome activation.
Fabiola Olivieri, A. Giuliani, M. Bonafè   +2 more
semanticscholar   +1 more source

Inflammaging and the skin

The Journal of Investigative Dermatology, 2020
As global life expectancy continues to rise we are challenged with maintaining health into old age. One strategy is to target the chronic low level inflammation associated with aging, termed ‘inflammaging’. This is characterized by increased levels of circulating pro-inflammatory cytokines and a shift toward cellular senescence; changes that are ...
Pilkington, Suzanne, Bulfone-Paus, Silvia, Griffiths, CEM, Watson, Rachel   +3 more
openaire   +1 more source

Immunosenescence and Inflammaging in Dogs and Cats: A Narrative Review

Journal of Veterinary Internal Medicine
A consistent and important feature of biological aging is the change in the types and functions of cells comprising the immune system. Across various mammalian species, this change follows consistent patterns, including diminished protective capacity ...
Brennen McKenzie
semanticscholar   +1 more source

The Role and Implications of Epidermal Dysfunction in the Pathogenesis of Inflammaging.

Journal of Investigative Dermatology
Inflammaging has long been linked to the pathogenesis of various aging-associated disorders, including cardiovascular disease, obesity, type 2 diabetes, and dementia. Yet, the origins of inflammaging remain unclear.
Jiechen Zhang, Bijun Xia, J. Wakefield, Peter M. Elias, Xiaohua Wang   +4 more
semanticscholar   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advancement of science
Epigenetic clocks in blood have shown promise as tools to quantify biological age, displaying robust associations with morbidity and all‐cause mortality.
Xiaolong Guo, J. Robertson, Andrea Aparicio, K. Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte Am Cecil, B. Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica A Lasky-Su, Ryan Smith, R. Marioni, Andrew E. Teschendorff   +17 more
semanticscholar   +1 more source

Immune Aging, Immunosenescence, and Inflammaging: Implications for Vaccine Response in Older Adults

Health Science Reports
Population aging is a significant demographic change while vaccines are mostly made for children and young adults and their effectiveness might be low in the older population.
Sahab Falahi, Amir Abdoli, A. Kenarkoohi
semanticscholar   +1 more source