Results 161 to 170 of about 197,632 (380)

NLRP3 inflammasome activation and cell death

Cellular & Molecular Immunology, 2021
Yi Huang, Wenjing Xu, Rongbin Zhou
semanticscholar   +1 more source

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Nature Communications, 2019
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Corey Rogers, Dan A Erkes, A. Nardone, A. Aplin, T. Fernandes‐Alnemri, E. Alnemri   +5 more
semanticscholar   +1 more source

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

Inflammasomes, neutrophil extracellular traps, and cholesterol

Journal of Lipid Research, 2019
Activation of macrophage inflammasomes leads to interleukin (IL)-1β and IL-18 secretion and promotes atherosclerosis and its complications in mice and humans.
Alan R. Tall, Marit Westerterp
doaj   +1 more source

Cellular Pyrin Domain-Only Protein 2 Is a Candidate Regulator of Inflammasome Activation [PDF]

, 2006
Andrea Dorfleutner, Nicole Bryan, Siera Jo Talbott, Kristin N. Funya, Stephanie L. Rellick, John C. Reed, Xianglin Shi, Yon Rojanasakul, Daniel C. Flynn, Christian Stehlik   +9 more
openalex   +1 more source

Structural mechanism for NEK7-licensed NLRP3 inflammasome activation

Nature, 2019
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly and activation of the NLRP3 inflammasome in interphase. Here we report a
H. Sharif, Li Wang, W. L. Wang, V. Magupalli, Liudmila Andreeva, Q. Qiao, Arthur V. Hauenstein, Zhaolong Wu, G. Núñez, Youdong Mao, Hao Wu   +10 more
semanticscholar   +1 more source

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

Advanced Science, EarlyView.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo, Mingliang Ma, Dan Wang, Ling Luo, Xueming Xu, Lingmin Huang, Fupeng Wang, Guangyan Kuang, Huiqi Liu, Rui Ni, Xin Li, Qinghua Zhang, Shengfeng Wang, Kai Zhao   +13 more
wiley   +1 more source

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling [PDF]

, 2007
Thirumala‐Devi Kanneganti, Mohamed Lamkanfi, Yun‐Gi Kim, Grace Chen, Jong‐Hwan Park, Luigi Franchi, Peter Vandenabeele, Gabriel Núñez   +7 more
openalex   +1 more source

Honeysuckle‐Derived Nanovesicles Regulate Gut Microbiota for the Treatment of Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study explores honeysuckle‐derived nanovesicles (HNVs) for treating inflammatory bowel disease. Orally administered HNVs alleviates colitis in mice by repairing the gut barrier, reducing inflammation, and restoring a healthy gut microbiota.
Yuanyuan Wang, Yuanhao Zhou, Qingyuan Wu, Yishu Li, Yilin Huang, Kexin Yu, Ping Li, Zhenye Lv, Haotian Liu, Hai Zou, Huiyu Liu, Xiaozhou Mou   +11 more
wiley   +1 more source

COPs and POPs: Modulators of Inflammasome Activity [PDF]

, 2007
Christian Stehlik, Andrea Dorfleutner
openalex   +1 more source