Results 181 to 190 of about 103,226 (265)

Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP. [PDF]

Sci Adv
Robin N, Barra NG, Foley KP, Li YE, Tamrakar AK, Patoli D, Rebalka IA, Cree T, Bibby K, Nguyen K, Davis R, Chan DY, Duggan BM, Henriksbo BD, Borges ME, Kukje Zada D, Fang H, Marko DM, Gregorevic P, Watt KI, Mills RJ, Sweeney G, Hawke TJ, Py BF, Schertzer JD.   +24 more
europepmc   +1 more source

Silymarin attenuates diabetic nephropathy in rats via modulation of the miRNA-223/NLRP3/caspase-1/GSDMD axis and inflammasome-related pyroptotic signaling. [PDF]

Biol Direct
Aboismaiel MG, Amin MN, Eissa LA.
europepmc   +1 more source

Deciphering the NEK7-NLRP3 inflammasome assembly: from conformational activation to allosteric drug discovery. [PDF]

Front Immunol
Gu CL, Liu DD, Chen H, Wei XH, Shang HC.
europepmc   +1 more source

Direct and indirect evidence for pyroptosis and immune dysregulation in IVF/ICSI-ET-related early pregnancy loss. [PDF]

Front Immunol
Wang X, Chen G, Liu F.
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Innate immune crosstalk in ALS/FTD pathogenesis. [PDF]

Cell Insight
Shu X, Yu X, Xu P, Wang A.
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The NLRP3 Inflammasome: A Central Mediator in Sevoflurane-Induced Neurotoxicity and A Potential Target for Neuroprotection. [PDF]

Mol Neurobiol
Li N, Chen Y, Chen G.
europepmc   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Inflammasome Gene Polymorphisms (NLRP3 and NLRC4) and Vitamin D Status in Patients with Multiple Sclerosis. [PDF]

Int J Mol Sci
Scazzone C, Agnello L, Gambino CM, Bellia C, Salemi G, Masucci A, Novara S, Ciaccio M.   +7 more
europepmc   +1 more source