Results 201 to 210 of about 177,383 (332)

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Emerging Role of the NLRP3 Inflammasome in the Onset of Oral Diseases and Its Potential as a Therapeutic Target. [PDF]

Int J Mol Sci
Alam MI, Farhana F, Sakai E.
europepmc   +1 more source

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma [PDF]

, 2017
Zili Zhai, Wen-Ting Liu, Manjinder Kaur, Y. Luo, Joanne Domenico, Jenny Mae Samson, Yiqun G. Shellman, David A. Norris, Charles A. Dinarello, Richard A. Spritz, Mayumi Fujita   +10 more
openalex   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

NLRP3 inflammasome regulates Th17/Treg cell balance in experimental autoimmune myocarditis. [PDF]

Biochem Biophys Rep
Su L, Qu N, Chen L, Lin Y, Mo H, Huang Y.   +5 more
europepmc   +1 more source

Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome

Arthritis &Rheumatology, EarlyView.
Serum cytokine profiling was performed using Luminex (48 cytokines) and ELISA (5 cytokines). Assessment of key cytokines (IFN‐α, IL‐18, IL‐6, CXCL9) delineated five dominant inflammatory patterns: I, IFN‐α–dominant CSS; II, IL‐18–dominant CSS; III, IL‐6–dominant CSS; IV, IFN‐γ–dominant CSS; and V, IL‐6 & IFN‐γ intermediate CSS.
Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu, Yuko Akutsu, Yuko Hayashi, Mao Mizuta, Yasuo Nakagishi, Keiji Akamine, Naomi Iwata, Kenji Furuno, Takayuki Tanaka, Kazuyuki Ueno, Shuhei Fujita, Koji Yokoyama, Toshinori Minato, Kazushi Izawa, Takahiro Yasumi, Tadashi Matsubayashi, Tadashi Hosoya, Hiroki Nishikawa, Junya Fujimura, Ryoko Asano, Yuko Sugita, Kenichi Watanabe, Anna Kobayashi, Takuya Endo, Katsuhide Eguchi, Ryuta Nishikomori, Ryuhei Yasuoka, Takaki Asano, Miyako Kanno, Kazuya Hamada, Yuji Fujita, Daisuke Hayashi, Shojiro Watanabe, Takeshi Shiba, Shinsuke Yasuda, Masaaki Mori, Hirokazu Kanegane, Masatoshi Takagi, Masaki Shimizu   +42 more
wiley   +1 more source

Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases. [PDF]

Mol Neurodegener
Jia H, Ma L, Liu J, Gao M, Liang X, Zhang F, Gao Y, Liu M, Jiang W, Wei M, Zhong X.   +10 more
europepmc   +1 more source

LBH589 inhibited NLRP3 inflammasome activation and pyroptosis in BMDMs.

Changwen Ning (15071847), Fenghua Gao (445421), Zhe Wang (41178), Huaying An (597769), Pengyu Liu (2575567), Yanan Sun (316649), Ru Li (109562), Zhuyang Song (21982901), Yuanyuan Yuan (1973092), Jinlong Li (388896), Jun Ma (9393), Xingwei Jiang (527377), Qun Yu (164003)   +12 more
openalex   +1 more source

The Role of Txnip in Mitophagy Dysregulation and Inflammasome Activation in Diabetic Retinopathy: A New Perspective

, 2017
Lalit P. Singh
openalex   +1 more source

Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption

, 2021
Yael Alippe, Dustin Kress, Biancamaria Ricci, Kai Sun, Tong Yang, Chun Wang, Jianqiu Xiao, Yousef Abu‐Amer, Gabriel Mbalaviele   +8 more
openalex   +1 more source