Results 241 to 250 of about 177,383 (332)

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

, 2017
David Furman, Junlei Chang, Lydia Lartigue, Christopher R. Bolen, François Haddad, Brice Gaudillière, Edward A. Ganio, Gabriela K. Fragiadakis, Matthew H. Spitzer, Isabelle Douchet, Sophie Daburon, Jean‐François Moreau, Garry P. Nolan, Patrick Blanco, Julie Déchanet‐Merville, Cornelia L. Dekker, Vladimir Jojic, Calvin J. Kuo, Mark M. Davis, Benjamin Faustin   +19 more
openalex   +2 more sources

Nano‐networks via reaction‐induced self‐assembly coordinate spatiotemporal multi‐drug delivery for acute kidney injury therapy

BMEMat, EarlyView.
Multifunctional nano‐networks (NNWs) are prepared via reaction‐induced self‐assembly (RISA) of spermidine (SPD), epigallocatechin gallate (EGCG), 2‐formylphenylboronic acid (2‐FPBA), and deferoxamine (DFO) through dynamic iminoboronate bonds. These NNWs leverage the oxidative AKI microenvironment to trigger disintegration, enabling site‐specific ...
Juan Jin, Xiao Zhang, Chenxi Wang, Taian Jin, Xinyang Fang, Yixuan Gao, Mengchun Chen, Weiyang Meng, Chang Gao, Wenlu Li, Yuanfeng Li, Yijie Chen, Calvin A. Omolo, Thirumala Govender, Linqi Shi, Yunguang Wang, Yong Liu, Qiang He   +17 more
wiley   +1 more source

Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks. [PDF]

Front Immunol
Qian X, Sun J, Li F, Xu L, Hu X, Dong N, Li G.   +6 more
europepmc   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis

, 2014
Chen Yang, Xiang Li, Krishna M. Boini, Ashley Pitzer, Erich Gulbins, Sunny Zhang, Pin‐Lan Li   +6 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Temporal Expression of NLRP3 Inflammasome Components in Patients with Acute Coronary Syndrome. [PDF]

Life (Basel)
Papanikolaou P, Aggelopoulos A, Antonopoulos AS, Theofilis P, Gazouli M, Tsioufis K, Tousoulis D.   +6 more
europepmc   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

PML Is Limiting NLRP3 Inflammasome Activity in Human Endothelial Cells. [PDF]

Cells
Liem CH, Steinemann G, Ghiroltean N, Yvonne Y, Sakr H, Nguyen H, Baum O, Berkholz J.   +7 more
europepmc   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source