Results 261 to 270 of about 119,990 (313)

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

SYK Signalling in NLRP3 Inflammasome-Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [PDF]

Eur J Immunol
Mašalaitė K, Norkienė M, Žvirblienė A, Lučiūnaitė A.   +3 more
europepmc   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney disease. [PDF]

Front Immunol
Jiang X, Huang W, Wen W, Liu T, Ren W, Shi J, He J, Du X.   +7 more
europepmc   +1 more source

Two inflammasomes as tumour markers for nonmelanocytic skin cancer: new hopes for early detection and targeted therapy. [PDF]

Skin Health Dis
Khayyat A, Zohouri SA, Pour MAE, Hatami P, Smoller BR.   +4 more
europepmc   +1 more source

Lipopolysaccharides Drive Proinflammatory Extracellular Vesicle Secretion in Coronary Artery Endothelial Cells via Noncanonical Inflammasome Activation. [PDF]

Cell Mol Life Sci
Nurmi K, Lorey MB, Parantainen J, Cypryk W, Kalogerakou E, Kouri VP, Kaivola J, Bilicka M, Beklen A, Chen Y, Stensland M, Matikainen S, Nyman TA, Eklund KK.   +13 more
europepmc   +1 more source

Study of the temperature-related factors that activate the NLRP3 inflammasome in <i>Trichophyton schoenleinii</i> and their activation mechanisms. [PDF]

Front Cell Infect Microbiol
Aimilajiang K, Wang X, Ji M, Abulizi P.
europepmc   +1 more source

Loss of Peroxiredoxin 6 Drives Age-Related Klf9/NF-<i>κ</i>B/Nlrp3 Inflammasome Activation and Pyroptosis: Therapeutic Rescue by Prdx6. [PDF]

Antioxidants (Basel)
Chhunchha B, Kubo E, Lehri D, Singh DP.
europepmc   +1 more source

When Infection Meets Inflammation: <i>Listeria monocytogenes</i> and Host Signaling Pathways. [PDF]

Biology (Basel)
Jia Y, Yang K, Guo R, Ding K, Wang S, Chen S.   +5 more
europepmc   +1 more source