Results 231 to 240 of about 109,193 (265)
Some of the next articles are maybe not open access.
Nature Reviews Immunology, 2012
Autophagosome formation accompanies inflammasome activation and acts to limit inflammasome activity.
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Autophagosome formation accompanies inflammasome activation and acts to limit inflammasome activity.
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2018
Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer).
Wanessa Cardoso, da Silva +3 more
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Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer).
Wanessa Cardoso, da Silva +3 more
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Nature Reviews Neuroscience, 2014
Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1
John G, Walsh +2 more
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Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1
John G, Walsh +2 more
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2018
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis.
Fabiola, Marín-Aguilar +2 more
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The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis.
Fabiola, Marín-Aguilar +2 more
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2018
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases.
Holly L, Hutton +2 more
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Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases.
Holly L, Hutton +2 more
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Nihon rinsho. Japanese journal of clinical medicine, 2013
Inflammation is a protective response intended to eliminate primary causes of tissue injury, leading to tissue repair and adaptation in a focal lesion. It is thought that various factors are involved in the histopathological responses to tissue injury.
Chikara, Okumura +4 more
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Inflammation is a protective response intended to eliminate primary causes of tissue injury, leading to tissue repair and adaptation in a focal lesion. It is thought that various factors are involved in the histopathological responses to tissue injury.
Chikara, Okumura +4 more
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2016
Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1.
Ann M, Janowski, Fayyaz S, Sutterwala
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Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1.
Ann M, Janowski, Fayyaz S, Sutterwala
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2018
Neuroinflammation is a common pathological feature in almost all neurological diseases and is a response triggered as a consequence of the chronic activation of the innate immune response in the CNS against a variety of stimuli, including infection, traumatic brain injury, toxic metabolites, aggregated proteins, or autoimmunity.
Albornoz, Eduardo A. +2 more
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Neuroinflammation is a common pathological feature in almost all neurological diseases and is a response triggered as a consequence of the chronic activation of the innate immune response in the CNS against a variety of stimuli, including infection, traumatic brain injury, toxic metabolites, aggregated proteins, or autoimmunity.
Albornoz, Eduardo A. +2 more
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2011
Inflammasomes are multiprotein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of Caspase-1 and IL-1β from cells of the innate immune system.
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Inflammasomes are multiprotein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of Caspase-1 and IL-1β from cells of the innate immune system.
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Nature Reviews Drug Discovery, 2023Mohamed Lamkanfi
exaly