Results 281 to 290 of about 119,990 (313)
Some of the next articles are maybe not open access.
2018
The current chapter focuses on the role of inflammasome in cancer prevention and development. Emerging evidence suggested that inflammasome is closely correlated with elevated levels of IL-1β and IL-18, activation of NF-κB signaling, enhanced mitochondrial oxidative stress, and activation of autophagic process in cancer.
Zhiyu, Wang +3 more
openaire +2 more sources
The current chapter focuses on the role of inflammasome in cancer prevention and development. Emerging evidence suggested that inflammasome is closely correlated with elevated levels of IL-1β and IL-18, activation of NF-κB signaling, enhanced mitochondrial oxidative stress, and activation of autophagic process in cancer.
Zhiyu, Wang +3 more
openaire +2 more sources
Nature Medicine, 2015
The NLRP3 inflammasome is involved in the molecular etiology of multiple autoinflammatory diseases. Two studies identify inhibitors of NLRP3 activation and might pave the way for new treatment options for a variety of diseases.
Maayan, Levy +2 more
openaire +2 more sources
The NLRP3 inflammasome is involved in the molecular etiology of multiple autoinflammatory diseases. Two studies identify inhibitors of NLRP3 activation and might pave the way for new treatment options for a variety of diseases.
Maayan, Levy +2 more
openaire +2 more sources
2018
Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer).
Wanessa Cardoso, da Silva +3 more
openaire +2 more sources
Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer).
Wanessa Cardoso, da Silva +3 more
openaire +2 more sources
2018
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis.
Fabiola, Marín-Aguilar +2 more
openaire +2 more sources
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis.
Fabiola, Marín-Aguilar +2 more
openaire +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 2013
Inflammation is a protective response intended to eliminate primary causes of tissue injury, leading to tissue repair and adaptation in a focal lesion. It is thought that various factors are involved in the histopathological responses to tissue injury.
Chikara, Okumura +4 more
openaire +3 more sources
Inflammation is a protective response intended to eliminate primary causes of tissue injury, leading to tissue repair and adaptation in a focal lesion. It is thought that various factors are involved in the histopathological responses to tissue injury.
Chikara, Okumura +4 more
openaire +3 more sources
2018
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases.
Holly L, Hutton +2 more
openaire +2 more sources
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases.
Holly L, Hutton +2 more
openaire +2 more sources
2016
Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1.
Ann M, Janowski, Fayyaz S, Sutterwala
openaire +2 more sources
Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1.
Ann M, Janowski, Fayyaz S, Sutterwala
openaire +2 more sources
2018
Neuroinflammation is a common pathological feature in almost all neurological diseases and is a response triggered as a consequence of the chronic activation of the innate immune response in the CNS against a variety of stimuli, including infection, traumatic brain injury, toxic metabolites, aggregated proteins, or autoimmunity.
Albornoz, Eduardo A. +2 more
openaire +5 more sources
Neuroinflammation is a common pathological feature in almost all neurological diseases and is a response triggered as a consequence of the chronic activation of the innate immune response in the CNS against a variety of stimuli, including infection, traumatic brain injury, toxic metabolites, aggregated proteins, or autoimmunity.
Albornoz, Eduardo A. +2 more
openaire +5 more sources
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Nature Reviews Drug Discovery, 2023Mohamed Lamkanfi
exaly
Targeting the NLRP3 inflammasome in inflammatory diseases
Nature Reviews Drug Discovery, 2018William R Roush +2 more
exaly