Results 71 to 80 of about 188,554 (379)
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship.
Frontiers in Cellular and Infection Microbiology, 2013 The production of IL-1β during the infection with Mycobacterium tuberculosis (Mtb) is important for successful host immune defense. In macrophages and dendritic cells the host cell inflammasome is crucial for generation of secreted IL-1β in response to ...
Volker eBriken +2 more
doaj +1 more source
ASN Neuro, 2021 Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage.
Rongrong Bai +5 more
doaj +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Cell Discovery, 2020 Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two.
D. Zheng, T. Liwinski, E. Elinav
semanticscholar +1 more source
Inhibiting the NLRP3 Inflammasome [PDF]
Molecules, 2020 Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy +2 more
openaire +4 more sources
A novel mechanism for NLRP3 inflammasome activation
Metabolism Open, 2022 The NLRP3 inflammasome, as an important component of the innate immune system, plays vital roles in various metabolic disorders. It has been reported that the NLRP3 inflammasome can be activated by a broad range of distinct stimuli, such as K+ efflux ...
Tan Zhang +6 more
doaj
Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome
Frontiers in Immunology, 2018 The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj +1 more source
Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]
, 2012 Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Bauer, Christian +4 more
core +1 more source
Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
Circulation Research, 2020 Supplemental Digital Content is available in the text. The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome.
A. Abbate +5 more
semanticscholar +1 more source
Atheroma and the inflammasome [PDF]
Journal of Nuclear Cardiology, 2015 Atherosclerosis is a ubiquitous disorder that begins in childhood. An autopsy study of 2,876 adolescents and young adults (ages 15-34) who died of external causes found fatty streaks in the aorta of 100% of subjects, and in the right coronary artery in half the subjects. The number and extent of lesions increased with age.
openaire +3 more sources