Results 91 to 100 of about 56,139 (234)
Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment. [PDF]
, 2015 The inflammasome is a complex of proteins that has a critical role in mounting an inflammatory response in reply to a harmful stimulus that compromises the homeostatic state of the tissue.
Chen, Shih-Wei +7 more
core +2 more sources
Journal of Neuroinflammation, 2018 Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 inflammasome in cerebral I/R has yet come to a conclusion ...
Zhe Gong +4 more
doaj +1 more source
Research Progress on the Role of Inflammasomes in Kidney Disease
Mediators of Inflammation, 2020 Inflammasomes are multimeric complexes composed of cytoplasmic sensors, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC or PYCARD), and procaspase-1 and play roles in regulating caspase-dependent ...
Kun Chi +4 more
doaj +1 more source
Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]
, 2012 Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Authier, Hélène +9 more
core +3 more sources
Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]
, 2015 Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core +1 more source
Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? [PDF]
, 2015 Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of the cell that are responsible for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, and the activation of a highly inflammatory ...
Abais, Justine M. +4 more
core +2 more sources
Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells [PDF]
, 2018 Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Grau, Veronika +11 more
core +1 more source
Reassessing the Evolutionary Importance of Inflammasomes [PDF]
, 2016 Inflammasomes monitor the cytosol for microbial contamination or perturbation, and are thus predicted to provide potent defense against infection. However, the compendium of data from murine infection models suggests that inflammasomes merely delay the ...
Maltez, Vivien I., Miao, Edward A.
core +2 more sources
Inflammation and premature aging in advanced chronic kidney disease [PDF]
, 2017 Systemic inflammation in end-stage renal disease (ESRD) is an established risk factor for mortality and a catalyst for other complications which are related to a premature aging phenotype, including muscle wasting, vascular calcification and other forms ...
Casper G. Schalkwijk +9 more
core +1 more source
Frontiers in Immunology, 2020 Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks).
Mikhail A. Gavrilin +19 more
doaj +1 more source