Results 31 to 40 of about 90,432 (374)
Inflammasomes: Mechanisms of Action and Involvement in Human Diseases
Cells, 2023 Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level.
D. Bulté +3 more
semanticscholar +1 more source
Inflammasomes and dermatology [PDF]
Anais Brasileiros de Dermatologia, 2016 Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the
Sá, Daniel Coelho de, Festa Neto, Cyro
openaire +5 more sources
Of inflammasomes and pathogens – sensing of microbes by the inflammasome [PDF]
EMBO Molecular Medicine, 2013 Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
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Frontiers in Immunology, 2022 BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was
Yan Qin +8 more
doaj +1 more source
Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes.
Annual Review of Immunology, 2022 Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and
Connie M. Ross +5 more
semanticscholar +1 more source
Inflammasomes, the eye and anti-inflammasome therapy [PDF]
Eye, 2017 Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein. Upon activation, caspase-1 induces maturation of cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18).
Yerramothu, P, Vijay, AK, Willcox, MDP
openaire +4 more sources
The role of inflammasomes in vascular cognitive impairment
Molecular Neurodegeneration, 2022 There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical role in disease onset and progression.
Luting Poh +9 more
semanticscholar +1 more source
Journal of Experimental Medicine, 2020 This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients. Activation of inflammasomes in moderate and severe cases of COVID-19 contributes to the exacerbated inflammatory response, impacting ...
T. Rodrigues +43 more
semanticscholar +1 more source
Inflammasomes and autoimmunity [PDF]
Trends in Molecular Medicine, 2011 The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components and danger signals. A subset of NLRs control inflammasome assembly that results in caspase-1 activation and, in turn, IL-1β and IL-18 production. Excessive inflammasome activation can cause autoinflammatory disorders, including the hereditary periodic fevers ...
Thirumala-Devi Kanneganti +2 more
openaire +3 more sources
Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases
Future Pharmacology, 2023 Inflammasomes, a group of multiprotein complexes, are essential in regulating inflammation and immune responses. Several inflammasomes, including nucleotide-binding domain leucine-rich repeat-containing protein 1 (NLRP1), NLRP3, NLRP6, NLRP7, NLRP12 ...
Sharmim Sultana +7 more
doaj +1 more source