Results 141 to 150 of about 3,017,933 (248)

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair. [PDF]

Adv Sci (Weinh)
Souali-Crespo S, Rizk JG, Calvano E, Sahu R, Colovic E, Chabba I, Gilbart V, Grandgirard E, Morlet B, Cai Q, Metzger D, Duteil D.   +11 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lipoxin A4 Attenuates E. coli-Induced ARDS-Like Lung Injury in Mice via ALX/FPR2-Dependent Macrophage Reprogramming

Journal of Inflammation Research
Bingxue Zhang,1,2,* Meng Xu,1,3,4,* Yanling Deng,5,* Donghui Li,5 Jun Shen,1,3 Chun Pan,1,5 Hongli He1,5,61Department of Critical Care Medicine, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu ...
Zhang B, Xu M, Deng Y, Li D, Shen J, Pan C, He H   +6 more
doaj  

CGRP: the immune system's double agent - context-dependent roles in inflammation, resolution and cancer. [PDF]

Front Immunol
Assas MB.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Fatty Acid Metabolic Reprogramming in Rheumatoid Arthritis: Integrating Inflammation, Resolution Failure, and Joint Destruction. [PDF]

J Inflamm Res
Li T, Li G, Yang Y, Han L, Shen P, Ba X, Lin W, Yan J, Zhang R, Ma S, Tu S, Qin K.   +11 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing. [PDF]

Commun Biol
Gao J, Zhu D, Wang J, Khan MIU, Zhang A, Wen X, Li Q, Jin P, Shen C.   +8 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Keratin utilizes H₂S to promote HMGB1 sulfhydration for inflammation resolution. [PDF]

Redox Biol
Huang X, Bao W, Tang S, Li M, Sun Y, Ge H, Zhao Y, Yuan H, Pan X, Lin W, Wei Y, Han S, Wu W, Liu R, Duan JA.   +14 more
europepmc   +1 more source