Genomic instability in chronic airway inflammatory diseases
Biomedical Journal, 2015 Chronic airway inflammatory diseases are life-threatening conditions, including bronchial asthma, chronic obstructive pulmonary disease (COPD), and so on.
Zhengqiang Bao +5 more
doaj +3 more sources
PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases [PDF]
PPAR Research, 2012 Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease.
Yongchun Shen +3 more
doaj +2 more sources
Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease. [PDF]
Int J Mol Sci, 2022 In the lung, glycosaminoglycans (GAGs) are dispersed in the extracellular matrix (ECM) occupying the interstitial space between the capillary endothelium and the alveolar epithelium, in the sub-epithelial tissue and in airway secretions. In addition to playing key structural roles, GAGs contribute to a number of physiologic processes ranging from cell ...
Caird R +6 more
europepmc +4 more sources
Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease. [PDF]
Int J Mol Sci, 2019 Inflammatory airway disease, such as asthma and chronic obstructive pulmonary disease (COPD), is a major health burden worldwide. These diseases cause large numbers of deaths each year due to airway obstruction, which is exacerbated by respiratory viral ...
Manley GCA, Parker LC, Zhang Y.
europepmc +2 more sources
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease. [PDF]
Int J Mol Sci, 2022 Repurposing of the anthelminthic drug niclosamide was proposed as an effective treatment for inflammatory airway diseases such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Niclosamide may also be effective for the treatment of viral respiratory infections, such as SARS-CoV-2, respiratory syncytial virus, and influenza.
Ousingsawat J +8 more
europepmc +4 more sources
The role of airway infection in chronic obstructive pulmonary disease [PDF]
, 2006 PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core +4 more sources
The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
Journal of Inflammation Research, 2012 Isabel Vega-Carrascal, Emer P Reeves, Noel G McElvaneyRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandAbstract: T cell immunoglobulin and mucin ...
Vega-Carrascal I +2 more
doaj +1 more source
Niclosamide repurposed for the treatment of inflammatory airway disease. [PDF]
JCI Insight, 2019 Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD), are characterized by mucus hypersecretion and airway plugging. In both CF and asthma, enhanced expression of the Ca 2+ -activated Cl ...
Cabrita I +3 more
europepmc +4 more sources
Frontiers in Medicine, 2020 Asthma is an inflammatory disease of the airways that may result from exposure to allergens or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of breath.
Kenneth P. Hough +6 more
doaj +1 more source
Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint
Journal of Translational Medicine, 2020 Asthma is an inflammatory disease of the lung airway network, which is initiated and perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 cytokines.
Mohammad Afzal Khan
doaj +1 more source