Results 11 to 20 of about 158,758 (202)

Genomic instability in chronic airway inflammatory diseases

Biomedical Journal, 2015
Chronic airway inflammatory diseases are life-threatening conditions, including bronchial asthma, chronic obstructive pulmonary disease (COPD), and so on.
Zhengqiang Bao, Juan Xiong, Wen Li, Zhihua Chen, Huahao Shen, Songmin Ying   +5 more
doaj   +3 more sources

Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease. [PDF]

Int J Mol Sci, 2022
In the lung, glycosaminoglycans (GAGs) are dispersed in the extracellular matrix (ECM) occupying the interstitial space between the capillary endothelium and the alveolar epithelium, in the sub-epithelial tissue and in airway secretions. In addition to playing key structural roles, GAGs contribute to a number of physiologic processes ranging from cell ...
Caird R, Williamson M, Yusuf A, Gogoi D, Casey M, McElvaney NG, Reeves EP.   +6 more
europepmc   +4 more sources

Niclosamide repurposed for the treatment of inflammatory airway disease. [PDF]

JCI Insight, 2019
Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD), are characterized by mucus hypersecretion and airway plugging. In both CF and asthma, enhanced expression of the Ca2+-activated Cl- channel TMEM16A is detected in mucus-producing club/goblet cells and airway smooth muscle.
Cabrita I, Benedetto R, Schreiber R, Kunzelmann K.   +3 more
europepmc   +4 more sources

The role of TIM-containing molecules in airway disease and their potential as therapeutic targets

Journal of Inflammation Research, 2012
Isabel Vega-Carrascal, Emer P Reeves, Noel G McElvaneyRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandAbstract: T cell immunoglobulin and mucin ...
Vega-Carrascal I, Reeves EP, McElvaney NG   +2 more
doaj   +1 more source

Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint

Journal of Translational Medicine, 2020
Asthma is an inflammatory disease of the lung airway network, which is initiated and perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 cytokines.
Mohammad Afzal Khan
doaj   +1 more source

Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease. [PDF]

J Vet Intern Med, 2017
Abstract Background Airway hyperresponsiveness (AWHR), expressed as hypersensitivity (PC75RL) or hyperreactivity (slope of the histamine dose-response curve), is a feature of inflammatory airway disease (IAD) or mild equine asthma in horses. Glucocorticoids are used empirically to treat IAD.
Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ.   +4 more
europepmc   +5 more sources

The Novel Regulatory Role of the lncRNA–miRNA–mRNA Axis in Chronic Inflammatory Airway Diseases

Frontiers in Molecular Biosciences, 2022
Chronic inflammatory airway diseases, characterized by airway inflammation and airway remodelling, are increasing as a cause of morbidity and mortality for all age groups and races across the world. The underlying molecular mechanisms involved in chronic
Xin Qiao, Gang Hou, Yu-Lin He, Dong-Fang Song, Yi An, Abdullah Altawil, Xiao-Ming Zhou, Qiu-Yue Wang, Jian Kang, Yan Yin   +9 more
doaj   +1 more source

Prevalence of inflammatory bowel disease in patients with airways disease [PDF]

Respiratory Medicine, 2008
Case reports and case series have suggested an association between inflammatory bowel disease (IBD) and airways disease, but there are no data demonstrating a higher prevalence of IBD among patients with airways disease. Furthermore, no consistent radiological, pulmonary or pathological abnormalities have been demonstrated in patients with both ...
Raj, A, Birring, S, Green, R, Grant, A, de Caestecker, J, Pavord, I   +5 more
openaire   +3 more sources

Pathology of asthma

Frontiers in Microbiology, 2013
Asthma is a serious health and socioeconomic issue all over the world, affecting more than 300 million individuals. The disease is considered as an inflammatory disease in the airway, leading to airway hyperresponsiveness, obstruction, mucus hyper ...
Makoto eKudo, Yoshiaki eIshigatsubo, Ichiro eAoki   +2 more
doaj   +1 more source

Inflammatory bowel disease and airway diseases

World Journal of Gastroenterology, 2016
Airway diseases are the most commonly described lung manifestations of inflammatory bowel disease (IBD). However, the similarities in disease pathogenesis and the sharing of important environmental risk factors and genetic susceptibility suggest that there is a complex interplay between IBD and airway diseases.
Vutcovici, Maria, Brassard, Paul, Bitton, Alain   +2 more
openaire   +2 more sources