The Endogenous Th17 Response in NO
, 2013 Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T. +45 more
core +2 more sources
Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]
, 2014 Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core +1 more source
Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease. [PDF]
J Vet Intern Med, 2017 Abstract Background Airway hyperresponsiveness (AWHR), expressed as hypersensitivity (PC75RL) or hyperreactivity (slope of the histamine dose-response curve), is a feature of inflammatory airway disease (IAD) or mild equine asthma in horses. Glucocorticoids are used empirically to treat IAD.
Léguillette R +4 more
europepmc +5 more sources
Frontiers in Immunology, 2023 High mobility group box 1 (HMGB1), a ubiquitous chromatin-binding protein required for gene transcription regulation, is released into the extracellular microenvironment by various structural and immune cells, where it is known to act as an alarmin. Here,
Yun Mao, Sonika Patial, Yogesh Saini
doaj +1 more source
Role of microRNAs in inflammatory upper airway diseases [PDF]
Allergy, 2020 AbstractMicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules that modulate post‐transcriptional gene expression in physiological and pathological processes. miRNAs can silence target mRNAs through degradation or inhibition of translation, showing their pivotal role in the pathogenesis of many human diseases. miRNAs play
Valeria Tubita +6 more
openaire +2 more sources
Clinical presentation of Crohn's disease. Association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery [PDF]
, 2005 Background/Aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically ...
Gasztonyi, Beáta +24 more
core +3 more sources
The Role of CLCA Proteins in Inflammatory Airway Disease [PDF]
Annual Review of Physiology, 2009 Inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) exhibit stereotyped traits that are variably expressed in each person. In experimental mouse models of chronic lung disease, these individual disease traits can be genetically segregated and thereby linked to distinct determinants.
Anand C, Patel +2 more
openaire +2 more sources
Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD) [PDF]
, 2006 Hypersecretion and chronic phlegm are major symptoms of chronic obstructive pulmonary disease (COPD) but animal models of COPD with a defined functional hypersecretion have not been established so far.
David A Groneberg +17 more
core +1 more source
Constrictive Bronchiolitis and Ulcerative Colitis
Canadian Respiratory Journal, 1999 Pulmonary complications occur in an estimated 0.21% of patients with inflammatory bowel disease. The most common presentation of pulmonary manifestations is large airway disease, such as tracheobronchitis, chronic bronchitis or bronchiectasis.
Heather Ward +5 more
doaj +1 more source
Possible involvement of acetylcholine-mediated inflammation in airway diseases
Allergology International, 2018 Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs ...
Akira Koarai, Masakazu Ichinose
doaj +1 more source