Results 21 to 30 of about 158,758 (202)

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +1 more source

Fungal Microbiota in Chronic Airway Inflammatory Disease and Emerging Relationships with the Host Immune Response

Frontiers in Microbiology, 2017
The respiratory tract is a complex system that is inhabited by niche-specific communities of microbes including bacteria, fungi, and viruses. These complex microbial assemblages are in constant contact with the mucosal immune system and play a critical ...
Irene Zhang, Steven D. Pletcher, Andrew N. Goldberg, Bridget M. Barker, Emily K. Cope   +4 more
doaj   +1 more source

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T., Weiss Daniel J., Laura Hoyt, Daggett, Rebecca, Alcorn John F., Poynter, ME, Daggett, R, Daggett Rebecca, Martin, Rebecca A., Lundblad Lennart K. A., Martin, RA, Daniel J. Weiss (460686), Ather Jennifer L., Lennart K. A. Lundblad (49082), Jennifer L. Ather (460682), Rebecca Daggett (460683), Alcorn, John F., Poynter, Matthew E., Hoyt Laura, Laura Hoyt (460684), John F. Alcorn (298001), Hoyt, L, Martin Rebecca A., Lennart K A Lundblad, Rebecca A Martin, Lundblad, Lennart K. A., Rebecca A. Martin (435571), Hoyt, Laura, Weiss, Daniel J., Poynter Matthew E., Rebecca Daggett, John F Alcorn, Alcorn, JF, Benjamin T Suratt, Suratt, BT, Ather, Jennifer L., Daniel J Weiss, Matthew E. Poynter (435575), Weiss, DJ, Lundblad, LKA, Jennifer L Ather, Benjamin T. Suratt (460685), Ather, JL, Chu, Hong Wei, Matthew E Poynter, Suratt Benjamin T.   +45 more
core   +1 more source

NF-kappaB Signaling in Chronic Inflammatory Airway Disease

Biomolecules, 2015
Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders which differ in their underlying causes and phenotypes but overlap in patterns of pharmacological treatments.
Michael Schuliga
doaj   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Vessey, Rupert S. J., Holz, Olaf, Rudolf A. Jörres, Kai Richter, Simpson, Kathy J., Tal-Singer, Ruth, Helgo Magnussen, Magnussen, Helgo, Anthony Gibson, Stanislawa Janicki, Kanniess, Frank, Richter, Kai, Ruth Tal-Singer, Gibson, Anthony, Kathy J. Simpson, Frank Kanniess, Janicki, Stanislawa, Rupert S. J. Vessey, Jörres, Rudolf A., Olaf Holz   +19 more
core   +1 more source

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood.
Malcolm R Starkey, Richard Y Kim, Emma L Beckett, Heidi C Schilter, Doris Shim, Ama-Tawiah Essilfie, Duc H Nguyen, Kenneth W Beagley, Joerg Mattes, Charles R Mackay, Jay C Horvat, Philip M Hansbro   +11 more
doaj   +1 more source

Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]

, 2014
Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core   +1 more source

Role of microRNAs in inflammatory upper airway diseases [PDF]

Allergy, 2020
AbstractMicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules that modulate post‐transcriptional gene expression in physiological and pathological processes. miRNAs can silence target mRNAs through degradation or inhibition of translation, showing their pivotal role in the pathogenesis of many human diseases. miRNAs play
Valeria Tubita, Borja Callejas‐Díaz, Jordi Roca‐Ferrer, Concepció Marin, Zheng Liu, De Yun Wang, Joaquim Mullol   +6 more
openaire   +2 more sources

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease [PDF]

, 2013
Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD).
Groneberg, David A., David A Groneberg, Fischer, Axel, Frank R Scholz, Springer, Jochen, Jochen Springer, Groneberg, Jan David Alexander, Christian Peiser, Scholz, Frank R., Axel Fischer, Peiser, Christian, Q Dinh, Quarcoo, David, David Quarcoo, Dinh, Q. Thai   +14 more
core   +1 more source

TGF-β: The missing link in obesity-associated airway diseases?

Current Research in Pharmacology and Drug Discovery, 2021
Obesity is emerging as a global public health epidemic. The co-morbidities associated with obesity significantly contribute to reduced quality of life, mortality, and global healthcare burden.
Joanna Woo, Cynthia Koziol-White, Reynold Panettieri, Jr., Joseph Jude   +3 more
doaj   +1 more source