Results 21 to 30 of about 6,114,519 (189)

The Novel Regulatory Role of the lncRNA–miRNA–mRNA Axis in Chronic Inflammatory Airway Diseases

Frontiers in Molecular Biosciences, 2022
Chronic inflammatory airway diseases, characterized by airway inflammation and airway remodelling, are increasing as a cause of morbidity and mortality for all age groups and races across the world. The underlying molecular mechanisms involved in chronic
Xin Qiao, Gang Hou, Yu-Lin He, Dong-Fang Song, Yi An, Abdullah Altawil, Xiao-Ming Zhou, Qiu-Yue Wang, Jian Kang, Yan Yin   +9 more
doaj   +1 more source

Pathology of asthma

Frontiers in Microbiology, 2013
Asthma is a serious health and socioeconomic issue all over the world, affecting more than 300 million individuals. The disease is considered as an inflammatory disease in the airway, leading to airway hyperresponsiveness, obstruction, mucus hyper ...
Makoto eKudo, Yoshiaki eIshigatsubo, Ichiro eAoki   +2 more
doaj   +1 more source

Inflammatory bowel disease and airway diseases

World Journal of Gastroenterology, 2016
Airway diseases are the most commonly described lung manifestations of inflammatory bowel disease (IBD). However, the similarities in disease pathogenesis and the sharing of important environmental risk factors and genetic susceptibility suggest that there is a complex interplay between IBD and airway diseases.
Vutcovici, Maria, Brassard, Paul, Bitton, Alain   +2 more
openaire   +2 more sources

Fungal Microbiota in Chronic Airway Inflammatory Disease and Emerging Relationships with the Host Immune Response

Frontiers in Microbiology, 2017
The respiratory tract is a complex system that is inhabited by niche-specific communities of microbes including bacteria, fungi, and viruses. These complex microbial assemblages are in constant contact with the mucosal immune system and play a critical ...
Irene Zhang, Steven D. Pletcher, Andrew N. Goldberg, Bridget M. Barker, Emily K. Cope   +4 more
doaj   +1 more source

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease [PDF]

, 2013
Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD).
Groneberg, David A., David A Groneberg, Fischer, Axel, Frank R Scholz, Springer, Jochen, Jochen Springer, Groneberg, Jan David Alexander, Christian Peiser, Scholz, Frank R., Axel Fischer, Peiser, Christian, Q Dinh, Quarcoo, David, David Quarcoo, Dinh, Q. Thai   +14 more
core   +1 more source

NF-kappaB Signaling in Chronic Inflammatory Airway Disease

Biomolecules, 2015
Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders which differ in their underlying causes and phenotypes but overlap in patterns of pharmacological treatments.
Michael Schuliga
doaj   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Vessey, Rupert S. J., Holz, Olaf, Rudolf A. Jörres, Kai Richter, Simpson, Kathy J., Tal-Singer, Ruth, Helgo Magnussen, Magnussen, Helgo, Anthony Gibson, Stanislawa Janicki, Kanniess, Frank, Richter, Kai, Ruth Tal-Singer, Gibson, Anthony, Kathy J. Simpson, Frank Kanniess, Janicki, Stanislawa, Rupert S. J. Vessey, Jörres, Rudolf A., Olaf Holz   +19 more
core   +1 more source

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood.
Malcolm R Starkey, Richard Y Kim, Emma L Beckett, Heidi C Schilter, Doris Shim, Ama-Tawiah Essilfie, Duc H Nguyen, Kenneth W Beagley, Joerg Mattes, Charles R Mackay, Jay C Horvat, Philip M Hansbro   +11 more
doaj   +1 more source

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +2 more sources

TGF-β: The missing link in obesity-associated airway diseases?

Current Research in Pharmacology and Drug Discovery, 2021
Obesity is emerging as a global public health epidemic. The co-morbidities associated with obesity significantly contribute to reduced quality of life, mortality, and global healthcare burden.
Joanna Woo, Cynthia Koziol-White, Reynold Panettieri, Jr., Joseph Jude   +3 more
doaj   +1 more source