Results 21 to 30 of about 156,509 (154)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease

Biomolecules, 2015
Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders which differ in their underlying causes and phenotypes but overlap in patterns of pharmacological treatments.
Michael Schuliga
doaj   +1 more source

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood.
Malcolm R Starkey, Richard Y Kim, Emma L Beckett, Heidi C Schilter, Doris Shim, Ama-Tawiah Essilfie, Duc H Nguyen, Kenneth W Beagley, Joerg Mattes, Charles R Mackay, Jay C Horvat, Philip M Hansbro   +11 more
doaj   +1 more source

TGF-β: The missing link in obesity-associated airway diseases?

Current Research in Pharmacology and Drug Discovery, 2021
Obesity is emerging as a global public health epidemic. The co-morbidities associated with obesity significantly contribute to reduced quality of life, mortality, and global healthcare burden.
Joanna Woo, Cynthia Koziol-White, Reynold Panettieri, Jr., Joseph Jude   +3 more
doaj   +1 more source

Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease

Frontiers in Immunology, 2023
High mobility group box 1 (HMGB1), a ubiquitous chromatin-binding protein required for gene transcription regulation, is released into the extracellular microenvironment by various structural and immune cells, where it is known to act as an alarmin. Here,
Yun Mao, Sonika Patial, Yogesh Saini
doaj   +1 more source

PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases

PPAR Research, 2012
Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease.
Yongchun Shen, Lei Chen, Tao Wang, Fuqiang Wen   +3 more
doaj   +1 more source

Constrictive Bronchiolitis and Ulcerative Colitis

Canadian Respiratory Journal, 1999
Pulmonary complications occur in an estimated 0.21% of patients with inflammatory bowel disease. The most common presentation of pulmonary manifestations is large airway disease, such as tracheobronchitis, chronic bronchitis or bronchiectasis.
Heather Ward, Kendra L Fisher, Ranjit Waghray, Jody L Wright, Sharon E Card, Donald W Cockcroft   +5 more
doaj   +1 more source

Role of microRNAs in inflammatory upper airway diseases [PDF]

Allergy, 2020
AbstractMicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules that modulate post‐transcriptional gene expression in physiological and pathological processes. miRNAs can silence target mRNAs through degradation or inhibition of translation, showing their pivotal role in the pathogenesis of many human diseases. miRNAs play
Valeria Tubita, Borja Callejas‐Díaz, Jordi Roca‐Ferrer, Concepció Marin, Zheng Liu, De Yun Wang, Joaquim Mullol   +6 more
openaire   +2 more sources

Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease. [PDF]

J Vet Intern Med, 2017
Abstract Background Airway hyperresponsiveness (AWHR), expressed as hypersensitivity (PC75RL) or hyperreactivity (slope of the histamine dose-response curve), is a feature of inflammatory airway disease (IAD) or mild equine asthma in horses. Glucocorticoids are used empirically to treat IAD.
Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ.   +4 more
europepmc   +5 more sources

Possible involvement of acetylcholine-mediated inflammation in airway diseases

Allergology International, 2018
Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs ...
Akira Koarai, Masakazu Ichinose
doaj   +1 more source

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Frontiers in Pharmacology, 2019
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto   +8 more
doaj   +1 more source