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Influenza A Virus H5N1 Subtype: Resurgent Interspecies and Intercontinental Transmission, and a New Host [PDF]

Pathogens
It has been more than 25 years since the avian influenza A virus (IAV) H5N1 subtype emerged in humans in 1997. Since then, this virus has become endemic in poultry and wild birds and has been causing sporadic infections in humans.
Matloob Husain
doaj   +3 more sources

A study of analysis PB1-F2 protein of Influenza Viruses A/H1N1pdm09, A/ H3N2, and A/H5N1 [PDF]

Health Science Journal of Indonesia, 2016
Abstrak Tujuan. Protein PB1-F2 (polymerase basic 1-frame 2) adalah protein terbaru yang ditemukan pada virus Influenza dan telah terbukti berperan dalam induksi kematian sel dan patogenitas. Tujuan dari tulisan ini adalah untuk menganalisis protein PB1-
Hana Apsari Pawestri, I Gusti Ngurah Kade Mahardika   +1 more
doaj   +5 more sources

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. [PDF]

PLoS ONE, 2011
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Anna Hultberg, Nigel J Temperton, Valérie Rosseels, Mireille Koenders, Maria Gonzalez-Pajuelo, Bert Schepens, Lorena Itatí Ibañez, Peter Vanlandschoot, Joris Schillemans, Michael Saunders, Robin A Weiss, Xavier Saelens, José A Melero, C Theo Verrips, Steven Van Gucht, Hans J de Haard   +15 more
doaj   +10 more sources

Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells [PDF]

Respiratory Research, 2009
Background Highly pathogenic avian influenza (HPAI) H5N1 virus is entrenched in poultry in Asia and Africa and continues to infect humans zoonotically causing acute respiratory disease syndrome and death.
Yuen Kit M, Lo CK, Chui WH, Ho Carol CC, Yu Wendy CL, Chan Renee WY, Chan Michael CW, Guan Yi, Nicholls John M, Peiris JS Malik   +9 more
doaj   +4 more sources

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

Emerging Microbes and Infections, 2023
The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on the insect ...
Dexin Kong, Yanjuan He, Jiaxin Wang, Lanyan Chi, Xiang Ao, Hejia Ye, Weihong Qiu, Xiutong Zhu, Ming Liao, Huiying Fan   +9 more
doaj   +2 more sources

A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre-exposed to H1N1 influenza virus

Virology Journal, 2010
Background Highly pathogenic avian influenza virus subtype H5N1 infects humans with a high fatality rate and has pandemic potential. Vaccination is the preferred approach for prevention of H5N1 infection.
Chang Haiyan, Huang Chaoyang, Wu Jian, Fang Fang, Zhang Wenjie, Wang Fuyan, Chen Ze   +6 more
doaj   +2 more sources

Avian influenza (H5N1) virus, epidemiology and its effects on backyard poultry in Indonesia: a review [version 2; peer review: 2 approved]

F1000Research, 2023
Avian influenza (AI) is a zoonotic viral endemic disease that affects poultry, swine, and mammals, including humans. Highly pathogenic avian influenza (HPAI) is caused by influenza type A virus subtypes H5, and H7 which are naturally carried by a wild ...
Mustofa Helmi Effendi, Adiana Mutamsari Witaningruma, Rao Zahid Abbas, Kashif Hussain, Ugbo Emmanuel Nnabuikeb, Asghar Abbas, Saifur Rehman, Muhammad Bilal   +7 more
doaj   +2 more sources

Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin [PDF]

, 2014
Influenza viruses continuously undergo antigenic changes with gradual accumulation of mutations in hemagglutinin (HA) that is a major determinant in subtype specificity.
Cho, Ki Joon, Hong, Kwang W, Kim, Kyung Hyun, Kim, Se-Ho, Kim, Sella, Lee, Ji-Hye, Saelens, Xavier, Seok, Jong Hyeon   +7 more
core   +18 more sources

Serological survey for avian influenza virus infection of backyard poultry and poultry workers in Baghdad and Basrah provinces, Iraq [PDF]

Bulgarian Journal of Veterinary Medicine, 2020
The aim of this study was to determine the prevalence of avian influenza virus (AIV) subtype H5N1 among backyard birds and poultry workers. The study included backyard birds (chickens and ducks) in rural areas of Baghdad and Basrah provinces, Iraq. Rural
S. Jaber, H. T. Thwiny
doaj   +1 more source

Truncation or Deglycosylation of the Neuraminidase Stalk Enhances the Pathogenicity of the H5N1 Subtype Avian Influenza Virus in Mallard Ducks

Frontiers in Microbiology, 2020
H5N1 subtype avian influenza virus (AIV) with a deletion of 20 amino acids at residues 49–68 in the stalk region of neuraminidase (NA) became a major epidemic virus.
Su-juan Chen, Keji Quan, Dandan Wang, Yinping Du, T. Qin, D. Peng, Xiufan Liu   +6 more
semanticscholar   +1 more source