Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Tracking down on 50-year History of Research about Information Management and Technology in Korea
Dept. of Domestic Information Information Service Center Korea Institute of Science and Technology Information
doaj +1 more source
Das liest die LIBREAS, Nummer #9 [Herbst / Winter 2021]
Redaktion LIBREAS
doaj +1 more source
The outlook of final-year students in information science on the world of work
Background: The principle of co-creation in curriculum design has become fundamental in recent times, necessitating the multiplicity of relevant voices to speak into curriculum design.
Martie A. Mearns, Elmi Bester
doaj +1 more source
Geographic information science in the era of geospatial big data: A cyberspace perspective. [PDF]
Liu X +21 more
europepmc +1 more source
Special issue on advances in data, information and knowledge engineering in data science era [PDF]
Ladjel Bellatreche, A Min Tjoa
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
REGIONAL AND LOCAL JOURNALS IN THE ACADEMIC ECOSYSTEM
The increasing centralization of scientific publishing has forced high-impact journals to emphasize globally accessible research, potentially diminishing the visibility of findings that hold significance in a local context.
Burhan Fatih Kocyigit +3 more
doaj +1 more source
Factors affecting time to publication in information science. [PDF]
Taşkın Z +3 more
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

