Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Das liest die LIBREAS, Nummer #3 (Sommer / Herbst 2018)
Library Ideas, 2018 Redaktion Libreas
doaj +1 more source
Talent management of library and information science professionals: A review of research and future directions. [PDF]
F1000ResRautaray B, Swain DK, Swain C.
europepmc +1 more source
Measuring researchers' potential scholarly impact with structural variations: Four types of researchers in information science (1979-2018). [PDF]
PLoS One, 2020 Hou J, Hou J, Yang X, Chen C.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Princípios científicos que direcionam a ciência e a tecnologia da informação digital
TransinformaçãoNo quadro de um projeto epistemológico, apresenta-se um breve estudo crítico de cinco princípios científicos que direcionam e caracterizam, atualmente, os novos paradigmas informacionais presentes na Ciência e na Tecnologia da Informação Digital.
Yves-François Le Coadic
doaj
Competencies required to make use of Information Science and Technology among Japanese medical students: a cross-sectional study. [PDF]
BMC Med EducOta Y, Asada Y, Mieno M, Matsuyama Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Enhancing the quality and efficiency of regulatory science literature reviews through innovation and collaboration with library and information science experts. [PDF]
Front Med (Lausanne)Stevens ER, Laynor G.
europepmc +1 more source