Results 61 to 70 of about 6,691 (240)

Single‐Nuclei Resolution of Intermuscular Adipose Tissue Indicates an Inflammation‐Associated Cellular Profile in Individuals With Knee Osteoarthritis: Findings From the SOMMA KOA Ancillary Study

Aging Cell, Volume 25, Issue 1, January 2026.
Interrogation of the cellular and transcriptional profile of IMAT in individuals with KOA reveals a pro‐inflammatory phenotype. ABSTRACT Individuals with knee osteoarthritis (KOA) have skeletal muscle changes around the knee joint including reduced quadricep muscle mass and increased intermuscular adipose tissue (IMAT).
Line O. Elingaard‐Larsen, Katie L. Whytock, Adeline Divoux, Cheehoon Ahn, Giovanna Distefano, Bret H. Goodpaster, Paul M. Coen, Jamie N. Justice, Erin E. Kershaw, Nancy E. Lane, Lauren M. Sparks   +10 more
wiley   +1 more source

Genetic mapping of distal femoral, stifle, and tibial radiographic morphology in dogs with cranial cruciate ligament disease.

PLoS ONE, 2019
Cranial cruciate ligament disease (CCLD) is a complex trait. Ten measurements were made on orthogonal distal pelvic limb radiographs of 161 pure and mixed breed dogs with, and 55 without, cranial cruciate partial or complete ligament rupture.
Eleni Healey, Rachel J Murphy, Jessica J Hayward, Marta Castelhano, Adam R Boyko, Kei Hayashi, Ursula Krotscheck, Rory J Todhunter   +7 more
doaj   +1 more source

Quercetin Alleviates Osteoarthritis Pain by Inhibiting Vascular Endothelial Growth Factor A Through Regulating cGAS/STING Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Knee osteoarthritis (KOA), a common degenerative joint disease marked by pain, inflammation and cartilage degradation, has been increasingly associated with dysregulated innate immune signalling. Among the implicated molecular pathways, cGAS/STING has emerged as a key modulator in both disease pathogenesis and therapeutic intervention ...
Enrui Hu, Yibao Wei, Taiyang Liao, Deren Liu, Zijian Gong, Jun Mao, Peimin Wang, Nongshan Zhang   +7 more
wiley   +1 more source

Exploratory pilot study of infrapatellar fat pad inflammation and treatment response in anterior knee pain: a single-center, ultrasound-guided injection trial in osteoarthritis and non-OA cohorts

Egyptian Rheumatology and Rehabilitation
Background Osteoarthritis (OA) is a leading cause of knee pain, and the infrapatellar fat pad (IPFP) may play a role via local inflammation. Objective This exploratory pilot study assessed infrapatellar fat pad (IPFP) inflammation using Doppler ...
Amira Abd Allah, Nadia Salah, Mohammed Ali, Soha Eldessouki   +3 more
doaj   +1 more source

Patellar and Femoral Bone Morphology Is Associated With Overweight and Sports Participation in Young Adolescents

Journal of Orthopaedic Research, Volume 43, Issue 12, Page 2221-2232, December 2025.
ABSTRACT High levels of physical activity or high BMI during puberty could negatively influence bone and cartilage development. Little is known about the effects of loading on patellar and femoral bone shape in a young population. Therefore, we aim to identify the association between 3D patella and femur shape and biomechanical loading in a young ...
Rosemarijn van Paassen, Nazli Tumer, Jukka Hirvasniemi, Tom M. Piscaer, Amir.A. Zadpoor, Stefan Klein, Sita M. A. Bierma‐Zeinstra, Edwin H. G. Oei, Marienke van Middelkoop   +8 more
wiley   +1 more source

A case of synovial lipomatosis with chronic synovitis presenting as acute knee pain [PDF]

, 2014
Background: Synovial lipomatosis is a rare, benign, intra-articular lipoma-like lesion characterized by villous proliferation of the synovium, most commonly affecting the knee joint.
Sushma HM, Anoosha K, Vijay Shankar S, Amita K
core   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

A novel infrapatellar approach of ultrasound-guided intra-articular injection of the knee from both lateral and medial side: a case series

Therapeutic Advances in Musculoskeletal Disease, 2023
Knee osteoarthritis (OA) is common. Ultrasound-guided intra-articular injection (UGIAI) using the superolateral approach is currently the gold standard for treating knee OA, but it is not 100% accurate, especially in patients with no knee effusion ...
King Hei Stanley Lam, Yung-Tsan Wu, Kenneth Dean Reeves, Admir Hadzic, Mario Fajardo Perez, Sau Nga Fu   +5 more
doaj   +1 more source

Treadmill Running Induces Remodeling of the Infrapatellar Fat Pad in an Intensity-dependent Manner [PDF]

, 2021
Ni Zeng, Tao Liao, Xin-yuan Chen, Zhi-Peng Yan, Jie‐Ting Li, Guoxin Ni   +5 more
openalex   +1 more source

The Presence of Mechanoreceptors and Cortical Connections Support a Proprioceptive Role for Knee Plicae

Arthroscopy, Sports Medicine, and Rehabilitation, Volume 7, Issue 6, December 2025.
Purpose To determine histologically and electrophysiologically whether the plicae have a proprioceptive function. Methods Tissue samples were obtained from 36 plicae in 29 knees (including 7 bilateral cases). The samples included 20 suprapatellar, 10 medial patellar, and 6 infrapatellar plicae.
Cihangir Turemis, Ilker Senses, Mehmet Erduran, I. Halit Pinar   +3 more
wiley   +1 more source