Results 11 to 20 of about 64,020 (238)

Julien Poinssot and His Descendants

Revista de Historiografía, 2021
This paper discusses the scientific lives of Julien, Louis and Claude Poinssot (grandfather, father and son) and their important contribution to the study of ancient religions in North Africa, especially in Tunisia, including their intense engagement ...
María Fernández Portaencasa
doaj   +1 more source

Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2023
Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance.
Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo   +9 more
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Evaluación de una vacuna de ADN y su péptido recombinante contra inhibina alfa (165-300) sobre la respuesta inmune y fertilidad en ratones

Nova Scientia, 2018
Se evalúo la vacuna de ADN (INHA-DNA) y su péptido recombinante (INHA-rec) contra inhibina alfa (INHA) sobre la respuesta inmune y la fertilidad en ratones. Dieciséis ratones Balb/c fueron divididos en dos grupos, 8 cada uno.
Carlos Luna-Palomera, Juan González-González, Amanda Gayosso-Vázquez, Vianey Ramírez-Andoney, Nadia Florencia Ojeda-Robertos, Julio Armando Aguilar-Cabrales, Rogelio Alejandro Alonso-Morales   +6 more
doaj   +3 more sources

Recent Advances in Anti-Tuberculosis Drug Discovery Based on Hydrazide–Hydrazone and Thiadiazole Derivatives Targeting InhA

Pharmaceuticals, 2023
Tuberculosis is an extremely serious problem of global public health. Its incidence is worsened by the presence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis.
Yoanna Teneva, Rumyana Simeonova, V. Valcheva, V. Angelova   +3 more
semanticscholar   +1 more source

Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis

PLoS Genetics, 2023
As an oocyte-specific growth factor, bone morphogenetic protein 15 (BMP15) plays a critical role in controlling folliculogenesis. However, the mechanism of BMP15 action remains elusive. Using zebrafish as the model, we created a bmp15 mutant using CRISPR/
Yue Zhai, Xin Zhang, Cheng Zhao, Ruijing Geng, Kun Wu, Mingzhe Yuan, Nana Ai, Wei Ge   +7 more
semanticscholar   +1 more source

Inhibin Alpha Expression in Human Tumors: A Tissue Microarray Study on 12,212 Tumors

Biomedicines, 2022
As a result of its expression in corresponding normal cell types, inhibin alpha (INHA) is used as an immunohistochemical marker for adrenocortical neoplasms and testicular or ovarian sex cord stromal tumors.
Sören Weidemann, Nessar Ahmad Noori, Maximilian Lennartz, Viktor Reiswich, David Dum, Anne Menz, Viktoria Chirico, Claudia Hube-Magg, Christoph Fraune, Ahmed Abdulwahab Bawahab, Christian Bernreuther, Ronald Simon, Till S. Clauditz, Guido Sauter, Andrea Hinsch, Simon Kind, Frank Jacobsen, Stefan Steurer, Sarah Minner, Eike Burandt, Andreas H. Marx, Till Krech, Patrick Lebok, Franziska Büscheck, Doris Höflmayer   +24 more
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Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.

European journal of medicinal chemistry, 2023
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) affects 10 million people each year and the emergence of resistant TB augurs for a growing incidence.
Mélina Chebaiki, E. Delfourne, R. Tamhaev, S. Danoun, F. Rodriguez, P. Hoffmann, Emeline Grosjean, Fernanda Gonçalves, Joëlle Azéma-Despeyroux, Adrián Pál, Jana Korduláková, Nadège Preuilh, S. Britton, P. Constant, H. Marrakchi, L. Maveyraud, L. Mourey, C. Lherbet   +17 more
semanticscholar   +1 more source

Synthesis, Structural Investigations, DFT Calculations, and Molecular Docking Studies of Novel 2-(Substituted-Aryloxymethyl)-5-(Pyridin-4-yl)-1, 3, 4-Oxadiazoles: Highly Potential InhA and Cytochrome c Peroxidase Inhibitors

Polycyclic aromatic compounds (Print), 2023
We report derivatives of 2,5-disubstituted-1,3,4-oxadiazole as powerful anti-TB and antioxidant compounds. Using substituted aryloxy acetic acids (2a–f) and isoniazid (3) in the presence of phosphorus oxychloride, a series of new 2-(substituted ...
Madhura Datar, Ramagopal Dhanwad, Mohammad Javeed, Nagesh Gunavanthrao Yernale, Basavarajaiah Suliphuldevara Mathada   +4 more
semanticscholar   +1 more source

Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors [PDF]

Journal of Medicinal Chemistry, 2020
Tuberculosis (TB) remains a leading cause of mortality amongst infectious diseases worldwide. InhA, an enoyl ACP-reductase, has been the focus of numerous drug discovery efforts as this is the target of the first line pro-drug isoniazid. However, with resistance to this drug becoming more common the aim has been to find new clinical candidates that ...
Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G, Dias, David MG, Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G, Blundell, Tom L, Abell, Chris   +9 more
openaire   +3 more sources

Molecular Docking and Chemical Analysis of Alcohol Compounds (C16-C20) Bound to InhA Receptors as Mycobactericidal Candidates

Jurnal Kimia Sains dan Aplikasi, 2020
Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis. TB infection spreads through the air and is more likely when using inappropriate disinfectants in medical and laboratory equipment related to TB research.
Muhammad Iqbal Shihab, Gita Syahputra
doaj   +1 more source