Results 21 to 30 of about 30,063 (226)

Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice. [PDF]

PLoS ONE, 2011
Inhibin is an important marker of Sertoli cell (SC) activity in animals with impaired spermatogenesis. However, the precise relationship between inhibin and SC activity is unknown.
Kailai Cai, Guohua Hua, Sibtain Ahmad, Aaixin Liang, Li Han, Canjie Wu, Feifei Yang, Liguo Yang   +7 more
doaj   +1 more source

The Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology

Infection and Drug Resistance, 2021
Yanhua Song,1 Guirong Wang,2 Qiang Li,1 Rongmei Liu,1 Liping Ma,1 Qi Li,3 Mengqiu Gao1 1Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101149, People’s Republic of China; 2National Clinical Laboratory on ...
Song Y, Wang G, Li Q, Liu R, Ma L, Li Q, Gao M   +6 more
doaj  

Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction. [PDF]

PLoS ONE, 2010
Sertoli cells, the support cells of mammalian spermatogenesis, are regulated by a number of nuclear factors and express retinoblastoma (RB) tumor suppressor protein.
Roopa L Nalam, Claudia Andreu-Vieyra, Martin M Matzuk   +2 more
doaj   +1 more source

Distant survival for patients undergoing surgery using volatile versus IV anesthesia for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study

BMC Anesthesiology, 2020
Background Whether anesthesia type is associated with the surgical outcome of Hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) remains to be determined.
Xiao-Yan Meng, Xiu-Ping Zhang, Zhe Sun, Hong-Qian Wang, Wei-Feng Yu   +4 more
doaj   +1 more source

Identifikasi Keragaman Genetik Gen Inhibin Subunit Alpha (INHA) dan Inhibin Subunit Beta A (INHBA) Pada Sapi Peranakan Ongole (PO)

Jurnal Ternak Tropika, 2021
Gen Inhibin berperan dalam mengatur proliferasi sel, pertumbuhan kelenjar adrenal, hematopoiesis dan metabolisme tulang. Inhibin subunit alpha juga diketahui memiliki dampak yang signifikan terhadap berat badan, panjang tubuh dan lingkar badan ...
Rafika Febriani Putri, Chairdin Dwi Nugraha, Ahmad Furqon, Wike Andre Septian, Suyadi Suyadi   +4 more
doaj   +1 more source

Identification of Novel Inhibitor of Enoyl-Acyl Carrier Protein Reductase (InhA) Enzyme in Mycobacterium tuberculosis from Plant-Derived Metabolites: An In Silico Study

Antibiotics, 2022
Mycobacterium tuberculosis (M.tb.) enoyl-acyl carrier protein (ACP) reductase (InhA) is validated as a useful target for tuberculosis therapy and is considered an attractive enzyme to drug discovery.
Kratika Singh, Niharika Pandey, Firoz Ahmad, Tarun Kumar Upadhyay, Mohammad Hayatul Islam, Nawaf Alshammari, Mohd Saeed, Lamya Ahmed Al-Keridis, Rolee Sharma   +8 more
doaj   +1 more source

Effects of Enoyl-Acyl Protein Carrier Reductase Mutations on Physiochemical Interactions with Isoniazid: Molecular Dynamics Simulation

International Journal of Electrochemical Science, 2011
The resistance strains of Mycobacterium tuberculosis have complicated the tuberculosis management and therapy. Prior to the discovery of a more effective therapy, it is crucial to understand the molecular basis and physiochemical interaction for drug ...
Yee Siew Choong, Habibah A. Wahab
doaj   +1 more source

Fragment-Based Design of Mycobacterium Tuberculosis InhA Inhibitors [PDF]

Journal of Medicinal Chemistry, 2020
Tuberculosis (TB) remains a leading cause of mortality amongst infectious diseases worldwide. InhA, an enoyl ACP-reductase, has been the focus of numerous drug discovery efforts as this is the target of the first line pro-drug isoniazid. However, with resistance to this drug becoming more common the aim has been to find new clinical candidates that ...
Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G, Dias, David MG, Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G, Blundell, Tom L, Abell, Chris   +9 more
openaire   +3 more sources

INHA profiles.

, 2013
INHA in male neonate mice on days 1, 7, 10, 14, 21, 28, 35, and 56 post partum. The normalized ratio for INHA protein was calculated by dividing the mean signal intensity from 3 biological replicates by the mean signal intensity with ACTB.
Aaixin Liang (342700), Sibtain Ahmad (342699), Feifei Yang (334047), Liguo Yang (342702), Li Han (133163), Canjie Wu (342701), Kailai Cai (342696), Guohua Hua (342698)   +7 more
core   +1 more source

Investigations on mutations in katG gene and inhA promoter region associated with isoniazid resistance in the clinical isolates of mycobacterium tuberculosis from Tehran, Iran

Chronic Diseases Journal
BACKGROUND: Isoniazid (INH) is one of the first-line drugs used for the treatment of Mycobacterium tuberculosis (Mtb). This study aimed to determine the mutations in katG and inhA promoter regions associated with INH resistance in clinical isolates of ...
Shahrzad Shafiei, Kambiz Davari, Sabah Hasani   +2 more
doaj   +1 more source