Results 31 to 40 of about 64,020 (238)

Structure-based drug design of novel M. tuberculosis InhA inhibitors based on fragment molecular orbital calculations

Comput. Biol. Medicine, 2023
2-trans enoyl-acyl carrier protein reductase (InhA) is a promising target for developing novel chemotherapy agents for tuberculosis, and their inhibitory effects on InhA activity were widely investigated by the physicochemical experiments.
Naruedon Phusi, Y. Hashimoto, Naoki Otsubo, Kyohei Imai, Paptawan Thongdee, Darunee Sukchit, Pharit Kamsri, Auradee Punkvang, Khomson Suttisintong, P. Pungpo, N. Kurita   +10 more
semanticscholar   +1 more source

The Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology

Infection and Drug Resistance, 2021
Yanhua Song,1 Guirong Wang,2 Qiang Li,1 Rongmei Liu,1 Liping Ma,1 Qi Li,3 Mengqiu Gao1 1Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101149, People’s Republic of China; 2National Clinical Laboratory on ...
Song Y, Wang G, Li Q, Liu R, Ma L, Li Q, Gao M   +6 more
doaj  

Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA [PDF]

, 2018
Our findings reported herein, provide support for the benefits of including functional group complexity (FGC) within fragments when screening against protein targets such as Mycobacterium tuberculosis InhA.
Barros, David, Bates, Robert, Chung, Chun-Wa, Convery, Maire A., De Dios Anton, Paco, Encinas, Lourdes, Fernandez-Menendez, Raquel, Fletcher, Daniel, Green, Simon R., Huggett, Margaret, Mackenzie, Claire, Mendoza-Losana, Alfonso, Prati, Federica, Ray, Peter C., Wyatt, Paul G., Zeng, Jingkun, Zuccotto, Fabio   +16 more
core   +3 more sources

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption [PDF]

, 2019
Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs)
Cha, Young-Nam, Dinauer, Mary C., Jang, Jin Sun, Kang, In Soon, Kim, Chaekyun, Kim, Young-June, Lee, Zang Hee   +6 more
core   +2 more sources

Effect of recombinant human vascular endothelial growth factor on testis tissue xenotransplants from prepubertal boys: a three-case study [PDF]

, 2019
Research question Does recombinant human vascular endothelial growth factor (VEGF-165) improve the efficiency of human immature testis tissue (ITT) xenotransplantation?
Goossens, Ellen, Kadam, Prashant, Ntemou, Elissavet, Van Laere, Sven, Van Saen, Dorien, Vicini, Elena   +5 more
core   +1 more source

Distant survival for patients undergoing surgery using volatile versus IV anesthesia for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study

BMC Anesthesiology, 2020
Background Whether anesthesia type is associated with the surgical outcome of Hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) remains to be determined.
Xiao-Yan Meng, Xiu-Ping Zhang, Zhe Sun, Hong-Qian Wang, Wei-Feng Yu   +4 more
doaj   +1 more source

Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Molecular Docking

International Journal of Molecular Sciences, 2022
Tuberculosis (TB) caused by Mycobacterium tuberculosis is still a serious public health concern around the world. More treatment strategies or more specific molecular targets have been sought by researchers.
Maged A El Sawy, M. M. Elshatanofy, Y. El Kilany, K. Kandeel, Bassma H. Elwakil, M. Hagar, M. Aouad, F. Albelwi, N. Rezki, Mariusz Jaremko, E. El Ashry   +10 more
semanticscholar   +1 more source

Identifikasi Keragaman Genetik Gen Inhibin Subunit Alpha (INHA) dan Inhibin Subunit Beta A (INHBA) Pada Sapi Peranakan Ongole (PO)

Jurnal Ternak Tropika, 2021
Gen Inhibin berperan dalam mengatur proliferasi sel, pertumbuhan kelenjar adrenal, hematopoiesis dan metabolisme tulang. Inhibin subunit alpha juga diketahui memiliki dampak yang signifikan terhadap berat badan, panjang tubuh dan lingkar badan ...
Rafika Febriani Putri, Chairdin Dwi Nugraha, Ahmad Furqon, Wike Andre Septian, Suyadi Suyadi   +4 more
doaj   +1 more source

A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]

, 2012
Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank, Muschol-Steinmetz, Cornelia, Reinhard, Joscha, Reitter, Anke, Yuan, Juping   +4 more
core   +2 more sources

Effects of Enoyl-Acyl Protein Carrier Reductase Mutations on Physiochemical Interactions with Isoniazid: Molecular Dynamics Simulation

International Journal of Electrochemical Science, 2011
The resistance strains of Mycobacterium tuberculosis have complicated the tuberculosis management and therapy. Prior to the discovery of a more effective therapy, it is crucial to understand the molecular basis and physiochemical interaction for drug ...
Yee Siew Choong, Habibah A. Wahab
doaj   +1 more source