Results 161 to 170 of about 17,483 (305)

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Goal Displacement and Goal Conflicts in Circular Innovation Initiatives: Types and Mitigation Practices

Business Strategy and the Environment, EarlyView.
ABSTRACT Many firms set ambitious sustainability goals but these are frequently “displaced” by proxy goals that are easier to track and measure. However, the specific types of goal conflicts that follow from this displacement are poorly understood. We conducted a case study of circular innovation initiatives at a global MedTech company and identified ...
Wiebke Reim, Johan Frishammar, Debadrita Panda   +2 more
wiley   +1 more source

Effect of Remimazolam on the Incidence of Intraoperative Hypothermia Compared with Inhalation Anesthetics in Patients Undergoing Endoscopic Nasal Surgery: A Prospective Randomized Controlled Trial. [PDF]

Int J Med Sci
Cho SA, Lee SJ, Kwon W, Jung JY, You HJ, Yoon SE, Sung TY.   +6 more
europepmc   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

Epilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh, Kazushi Aoto, Atsuo Fukuda, Hirotomo Saitsu   +3 more
wiley   +1 more source

Reducing the carbon footprint of operating rooms through education on the effects of inhalation anesthetics on global warming: A retrospective study. [PDF]

Medicine (Baltimore)
Park EJ, Bae J, Kim J, Yoon JU, Do W, Yoon JP, Shon HS, Kang Y, Kim HY, Cho AR.   +9 more
europepmc   +1 more source

Mass culture of equine synovial fluid‐derived mesenchymal stromal cells using nonwoven polyethylene terephthalate fabrics

Equine Veterinary Journal, EarlyView.
Abstract Background Culture protocols need to yield 100 million equine synovial fluid (SF)‐derived mesenchymal stromal cells (SF‐MSCs) in around 3 weeks are needed, before these cells can be evaluated as agents of articular repair in clinical trials. Objectives To investigate mass culture of equine SF‐MSC culture protocols using nonwoven polyethylene ...
Miho Daniel Yoshitomi, Tomohide Kuramoto, Takashi Hatazoe, Kenta Mitsuda, Henry Smith, Kazuhiro Misumi   +5 more
wiley   +1 more source

Tracheal wash culture is not associated with bronchial infection, remodelling or inflammation in horses with asthma

Equine Veterinary Journal, EarlyView.
Abstract Background Antimicrobials are commonly prescribed for the treatment of equine asthma, despite limited evidence supporting their use. Tracheal wash (TW) bacterial culture results are known to influence antimicrobial prescription decisions. Objectives To determine whether a positive TW bacterial culture in horses with asthma is associated with ...
Laurence Leduc, Guillaume St‐Jean, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

XENON in medical area: emphasis on neuroprotection in hypoxia and anesthesia [PDF]

, 2013

core   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source