Results 101 to 110 of about 6,274,440 (386)

Virtual Reality-based Cognitive Intervention for Enhancing Executive Functions in Community-dwelling Older Adults

Psychosocial Intervention, 2022
With the rapid growth of the older population globally, it is anticipated that age-related cognitive decline in the prodromal phase and more severe pathological decline will increase.
Pattrawadee Makmee, Peera Wongupparaj
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

CDK4/6 inhibition triggers anti-tumor immunity

Nature, 2017
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies.
S. Goel, Molly J Decristo, April C. Watt, Haley BrinJones, Jaclyn Sceneay, Ben B. Li, N. Khan, Jessalyn M. Ubellacker, Shaozhen Xie, O. Metzger-Filho, J. Hoog, M. Ellis, Cynthia X. Ma, S. Ramm, I. Krop, E. Winer, T. Roberts, Hye-Jung Kim, S. McAllister, Jean J. Zhao   +19 more
semanticscholar   +1 more source

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +2 more sources

Limited Benefit of Sleep Extension on Cognitive Deficits During Total Sleep Deprivation: Illustration With Two Executive Processes

Frontiers in Neuroscience, 2019
Introduction: Sleep extension has been associated with better alertness and sustained attention capacities before, during and after sleep loss. However, less is known about such beneficial effect on executive functions (EFs).
Arnaud Rabat, Arnaud Rabat, Pierrick J. Arnal, Pierrick J. Arnal, Hortense Monnard, Hortense Monnard, Mégane Erblang, Mégane Erblang, Pascal Van Beers, Pascal Van Beers, Clément Bougard, Clément Bougard, Catherine Drogou, Catherine Drogou, Mathias Guillard, Mathias Guillard, Fabien Sauvet, Fabien Sauvet, Damien Leger, Damien Leger, Danielle Gomez-Merino, Danielle Gomez-Merino, Mounir Chennaoui, Mounir Chennaoui   +23 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Reducing the Amount of Microbiological Growth Using Ultrasonic Treatment [PDF]

, 1991
This thesis explored the possibility of using ultrasonic treatment to reduce the amount of microbiological growth in a sample of contaminated mill wastewater.
Gill, Mark
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Inhibition and Production of Anger Cost More: Evidence From an ERP Study on the Production and Switch of Voluntary Facial Emotional Expression

Frontiers in Psychology, 2019
Humans need to flexibly produce or switch different facial emotional expressions to meet social communication need. However, little is known about the control of voluntary facial emotional expression.
Chenyu Shangguan, Xia Wang, Xu Li, Yali Wang, Jiamei Lu, Zhizhuan Li   +5 more
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source