Results 1 to 10 of about 5,333,350 (348)

Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease

Biomolecules, 2022
Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination.
Xin Pan, Sihua Wu, Wenping Wei, Zixuan Chen, Yong Wu, Kaizheng Gong   +5 more
doaj   +1 more source

Criticality in EAP Education in Iran: a missing link [PDF]

Journal of English Language Teaching and Learning, 2022
Despite its importance, a review of the related literature reveals not many studies have examined criticality in EAP. Accordingly, in the present study, whether critical approaches were followed in Iranian EAP classes were investigated among EAP teachers
Hassan Soodmand Afshar, Shadi Donyaie
doaj   +1 more source

Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors

Molecules, 2022
Necroptosis has emerged as an exciting target in oncological, inflammatory, neurodegenerative, and autoimmune diseases, in addition to acute ischemic injuries.
Natália Aniceto, Vanda Marques, Joana D. Amaral, Patrícia A. Serra, Rui Moreira, Cecília M. P. Rodrigues, Rita C. Guedes   +6 more
doaj   +1 more source

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Science, 2020
Targeting a key enzyme in SARS-CoV-2 Scientists across the world are working to understand severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Zhang et al.
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, U. Curth, C. Drosten, Lucie Sauerhering, S. Becker, K. Rox, R. Hilgenfeld   +8 more
semanticscholar   +1 more source

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

International Journal of Molecular Sciences, 2021
Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two
Dan-in Jang, A-Hyeon Lee, Hye-Yoon Shin, Hyo-Ryeong Song, Jong-Hwi Park, T. Kang, Sang-Ryong Lee, Seung-Hoon Yang   +7 more
semanticscholar   +1 more source

Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter

mBio, 2020
The wall teichoic acid (WTA) is a major cell wall component of Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), a common cause of fatal clinical infections in humans. Thus, the indispensable ABC transporter TarGH, which
Li Chen, Wen-Tao Hou, Tao Fan, Banghui Liu, Ting Pan, Yu-Hui Li, Yong-Liang Jiang, Wen Wen, Zhi-Peng Chen, Linfeng Sun, Cong-Zhao Zhou, Yuxing Chen   +11 more
doaj   +1 more source

Corrosion inhibitors for enhanced strength, durability, and microstructure of coastal concrete structures

Materials Research Express, 2023
The prevalence of catastrophic structural member failure caused by steel corrosion in civil infrastructure underscores the importance of reducing reinforcement corrosion to enhance overall infrastructure costs, reliability, and sustainable development ...
Smrithy Subash, Lukesh Parida, Utsav Singh, Sumedha Moharana   +3 more
doaj   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

New England Journal of Medicine, 2020
RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan, O. Vardeny, T. Michel, J. McMurray, M. Pfeffer, S. Solomon   +5 more
semanticscholar   +1 more source

A Treg-Selective IL-2 Mutein Prevents the Formation of Factor VIII Inhibitors in Hemophilia Mice Treated With Factor VIII Gene Therapy

Frontiers in Immunology, 2020
Hemophilia A is a genetic disorder that results in the deficiency of functional factor VIII protein, which plays a key role in blood coagulation. Currently, the majority of hemophilia A patients are treated with repeated infusions of factor VIII protein.
Alex C. Chen, Xiaohe Cai, Chong Li, Liliane Khoryati, Marc A. Gavin, Carol H. Miao   +5 more
doaj   +1 more source

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Frontiers in Oncology, 2022
Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties.
Manzar Alam, Sarfraz Ahmed, Abdelbaset Mohamed Elasbali, Mohd Adnan, Shoaib Alam, Md. Imtaiyaz Hassan, Visweswara Rao Pasupuleti, Visweswara Rao Pasupuleti, Visweswara Rao Pasupuleti   +8 more
doaj   +1 more source