Results 1 to 10 of about 3,029,346 (287)
Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease
Biomolecules, 2022 Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination.
Xin Pan +5 more
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Criticality in EAP Education in Iran: a missing link [PDF]
Journal of English Language Teaching and Learning, 2022 Despite its importance, a review of the related literature reveals not many studies have examined criticality in EAP. Accordingly, in the present study, whether critical approaches were followed in Iranian EAP classes were investigated among EAP teachers
Hassan Soodmand Afshar, Shadi Donyaie
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Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors
Molecules, 2022 Necroptosis has emerged as an exciting target in oncological, inflammatory, neurodegenerative, and autoimmune diseases, in addition to acute ischemic injuries.
Natália Aniceto +6 more
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Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter
mBio, 2020 The wall teichoic acid (WTA) is a major cell wall component of Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), a common cause of fatal clinical infections in humans. Thus, the indispensable ABC transporter TarGH, which
Li Chen +11 more
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Materials Research Express, 2023 The prevalence of catastrophic structural member failure caused by steel corrosion in civil infrastructure underscores the importance of reducing reinforcement corrosion to enhance overall infrastructure costs, reliability, and sustainable development ...
Smrithy Subash +3 more
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Frontiers in Immunology, 2020 Hemophilia A is a genetic disorder that results in the deficiency of functional factor VIII protein, which plays a key role in blood coagulation. Currently, the majority of hemophilia A patients are treated with repeated infusions of factor VIII protein.
Alex C. Chen +5 more
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Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
Frontiers in Oncology, 2022 Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties.
Manzar Alam +8 more
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Frontiers in Immunology, 2021 Knowledge of glycogen synthase kinase 3β (GSK3β) activity and the molecules identified that regulate its function in infections caused by pathogenic microorganisms is crucial to understanding how the intensity of the inflammatory response can be ...
Ricarda Cortés-Vieyra +5 more
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Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases
Proteomes, 2015 Probing the dynamic activities of protein kinases in real-time in living cells constitutes a major challenge that requires specific and sensitive tools tailored to meet the particular demands associated with cellular imaging.
Juan A. González-Vera, May C. Morris
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Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
Molecules, 2018 A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green +2 more
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