Results 141 to 150 of about 2,365,869 (296)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Influence of Natural Complex Compounds with Hipolipidemic Activity on Expression of Bacteria Virulence Factors

Антибиотики и Химиотерапия, 2020
Natural complex compounds with hipolipidemic activity, having considerable inhibitory effect on expression of bacteria virulence factors were isolated. Inhibitory properties of the compounds with respect to pyocyanine and protease formation, as well as ...
V. Yu. Gotovtseva, N. E. Grammatikova, M. V. Bibikova, A. V. Katlinsky   +3 more
doaj  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Inhibitory SGLT-2 jako terapia adjuwantowa w leczeniu cukrzycy typu 1

, 2020
Bezwzględny niedobór insuliny, który występuje w cukrzycy typu 1 (DM T1) wiąże się z koniecznością stosowania intensywnej funkcjonalnej insulinoterapii jako jedynego właściwego modelu leczenia.
Cichocka, Edyta; Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, Poland, Maj-Podsiadło, Anna; Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, Poland, Gumprecht, Janusz; Katedra i Klinika Chorób Wewnętrznych, Diabetologii i Nefrologii w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, Poland   +2 more
core  

Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from <i>Salvia officinalis</i>. [PDF]

Biochem Biophys Rep, 2021
Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.   +13 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8

Natural Products and Bioprospecting
Seven previously undescribed polycyclic meroterpenoids talarines K–Q (1–7), along with five known ones (8–12), were isolated from desert-derived fungi Talaromyces sp. HMT-8. The structure of the novel compounds were elucidated using spectroscopic methods,
Xin-yi Zhai, Jin-jie Liu, Cui-duan Wang, Yi-fan Dou, Jian-hua Lv, Li-an Wang, Jin-xiu Zhang, Zhuang Li   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Antifungal efficacy of Thevetia peruviana leaf extract against Alternaria solani and characterization of novel inhibitory compounds by Gas Chromatography-Mass Spectrometry analysis. [PDF]

Biochem Biophys Rep, 2021
Meena BR, Meena S, Chittora D, Sharma K.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source